CEOInterviews.AI
Start App
Greg Smith
Chief Executive Officer, IP Group

IP Group – executive interview (27 Oct 2025)

📅 Oct 27, 2025 Edison 12 MIN 14014 VIEWS 17 SEGMENTS · 2 SPEAKERS
In this interview, IP Group’s CEO, Greg Smith, highlights the potentially transformational implications of Pfizer’s acquisition of Metsera (for up to $7.3bn, of which $4.9bn is in upfront cash), whose MET-097 anti-obesity drug is progressing through Phase II. IP Group is entitled to low single‑digit royalties from a number of Metsera compounds, including MET‑097. EvaluatePharma forecasts that MET-097 could generate $9.2bn in non-risk-adjusted revenue by 2032, implying significant royalty streams to IP Group if commercialisation is successful. Greg reiterates confidence in management’s target o...

Questions asked in this interview

6
  1. 0:30Can you explain the importance of that transaction?
  2. 2:05So if that's right, that could be a game-changer, couldn't it?
  3. 4:15Can you discuss that and what's driving that confidence in hitting that target?
  4. 6:50And looking outside of exits, are there any other particular things going on in the portfolio that we should be aware of?
  5. 10:11Moving on a bit, can we discuss the discussions about securing third-party capital?
  6. 11:57Lot going on in that area across the board, but we've recently had Nvidia's chief exec visiting the UK, and in particular highlighting a number of companies in your portfolio. Can you discuss that?
Dan 0:07 ↗
Hello and welcome to Edison TV. Today I'm joined by Greg Smith, chief executive officer of IP Group. IP Group are a UK listed investor in science-based companies across clean tech, deep tech, and life sciences. Greg, thanks for joining me again.
Greg Smith 0:27 ↗
Good to see you again, Dan. Thanks for having us.
Dan 0:30 ↗
So there've been several announcements regarding the technical and commercial progress across the portfolio recently. A particular highlight there was Pfizer's acquisition of Medicago. Can you explain the importance of that transaction?
Greg Smith 0:46 ↗
Yeah, so this is something that we highlighted in the half-year results for the first time. We haven't typically talked a lot about the licensing side of IP Group's business, mainly because for the past few years it's contributed sort of a few hundred thousand of income to the group. And one of the transactions this year that was quite interesting was the IPO of a business called Medicago, which has got a novel GLP-1, so one of the anti-obesity drugs, and that was progressing through into phase two. And they IPO'd, they raised a few hundred million, and so obviously we were quite interested because we licensed the fundamental technology behind their lead program and a number of their other programs to them on interesting commercial terms. The fact that they had raised a few hundred million by way of IPOs gave them the firepower to be able to develop that compound, which was big news. And at the time that we announced the results, we flagged this to shareholders. And then a week after the results, it was announced that Pfizer was acquiring the business for a 4.9 billion cash up front plus another couple of billion in milestones. And so I think that to us really highlighted the degree to which there could be some really significant potential value here.
Dan 2:05 ↗
And this could be very significant, couldn't it? We've actually just produced a report on this, but just to check the figures. So the consensus estimates are for the MET-97 drug to generate around 9.2 billion of revenue by 2030. And if we take a royalty of that of 1%, which I think is a baseline, that would imply that it could be generating around 90 million plus of annualized royalties for IP Group. So if that's right, that could be a game-changer, couldn't it?
Greg Smith 2:39 ↗
Yeah, I mean we're quite excited by the news. And we haven't put any financial information out there other than what we included in our RNS, but to say we do benefit from a low single-digit royalty. I think as always your analyst is close to the pulse and has picked up the scale of potential revenues that could come from the compound if it successfully gets through phase two and phase three and into the market. But yes, I mean if those numbers come to fruition, and that's just from the one lead compound, it's worth noting that we've got IP over a number of compounds that they're developing. So yeah, we're watching it closely. And I think from your viewers' point of view it's worth noting that this isn't something which is reflected in our NAV or our NAV per share. So I think that the total value in our books at the half-year was about 1.2 million or 1.5 million or something. It's a very small amount. So over the course of the next six months as hopefully the compound progresses through clinical trials, we will provide some further financial information. And already the analysts that cover us, Milos included, have started to give some indications of what the value could be for the group. But I think it's fair to say it could be quite significant for us, which would be great news for shareholders.
Dan 4:15 ↗
Yeah, obviously so we need to discount that back, but equally it's not fully in your own NAV at the moment. So one of the notable messages in your H1 results was the continued focus on delivering exits and that 250 million exit target by I think year end 2027. Can you discuss that and what's driving that confidence in hitting that target?
Greg Smith 4:42 ↗
Yeah, thanks for picking that one up. That was one we thought it was important to set out a longer-term ambition for the amount of cash we could realize from the portfolio. And 250 million in cash is quite a meaningful proportion of our 500 millionish market cap at the moment. So we're quite ambitious on this. But it wasn't with unfounded confidence. And I think the recent announcement of the acquisition of one of our portfolio companies in the AI space, Monolith, to Coreweave, one of the very big US Nasdaq listed businesses operating in that space, is hopefully a flavor of why we feel confident. Another transaction during the course of the first half of the year, which I haven't spoken about for a long while, was an IPO of one of our businesses. We were very pleased for Dan and Gabe and the team that they had a successful IPO of Hinge Health on the New York Stock Exchange. That's a business that we backed right from the very beginning; our first investment was about 50,000 pounds or something in the business. And we're already at the point, having taken a bit of cash off at the IPO, of having made a 50X type return on the amount that we invested. We invested almost a million dollars in the business. So that's very interesting. It's trading well in the aftermarket. And our remaining balance, which was about 40 million pounds of value or about 4-5 p per share as at the half-year, is currently under lockup. But of course it offers some opportunities for liquidity in the second half of the year and beyond. And there are other opportunities within the portfolio for realizations, and that's why we've got the confidence in saying that we can achieve that 250 million at least outside of our holding in Oxford Nanopore by the end of 2027.

8 more exchanges in this transcript

Sign in free to read the rest of this interview. No card required.

Sign in to read the full transcript

Cite this transcript

APA, MLA, BibTeX
APA

Smith, G. (2025, October 27). IP Group – executive interview (27 Oct 2025) [Interview transcript]. Edison. CEOInterviews.AI. https://ceointerviews.ai/interview/1109849/

MLA

Greg Smith. "IP Group – executive interview (27 Oct 2025)." Edison, 27 Oct. 2025. Transcript, CEOInterviews.AI, https://ceointerviews.ai/interview/1109849/.

BibTeX
@misc{smith2025_1109849,
  author       = {Greg Smith},
  title        = {IP Group – executive interview (27 Oct 2025)},
  howpublished = {Interview transcript, Edison. CEOInterviews.AI},
  year         = {2025},
  month        = {oct},
  url          = {https://ceointerviews.ai/interview/1109849/},
  note         = {Speaker-attributed transcript with timestamps}
}