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Bryan Johnson
American entrepreneur and venture capitalist, Don't Die

The Bryan Johnson & Kate Tolo Episode | Friends Keep Secrets

📅 Aug 25, 2026 Friends Keep Secrets and 4 more 69 MIN 78387 VIEWS 727 SEGMENTS · 4 SPEAKERS
Bryan Johnson is the longevity man. He has spent years measuring basically everything there is to measure about his body in an attempt not to die, and now he's brought his partner Kate Tolo over to measure us. This is concerning because we have been living very differently than these people. Bryan doesn't drink, doesn't eat at restaurants, goes to bed extremely early and has a list of 200 things that kill you in life. Kristin would like to know if she can still have wine and eat ten pounds of strawberries. Dave would like to know if sex holds value. Benny would like to know if Bryan ever sees...

What Bryan Johnson said

Written from the verified transcript and checked against it. Every figure links to the moment it was said.

Bryan Johnson discussed his longevity philosophy and practices, emphasizing sleep as the foundation of health and recommending lowering heart rate before bed. He advocated for daily 5 mg Tadalafil for most adults over 40, citing blood flow benefits. Johnson described his psilocybin and 5-MeO-DMT experiments, calling psilocybin a 'legitimate contender' as a longevity therapy and 5-MeO-DMT the 'crown jewel of conscious existence.' He framed AI as the key to humanity's potential to transcend death, calling it 'the only thing that matters right now.' Johnson detailed his diet (legumes, veggies, berries, nuts, seeds, olive oil), his avoidance of restaurants, and his microplastics reduction via sauna (87% lower after 21 sessions). He shared his origin story, including selling his company for a couple hundred million dollars, and his relationship with Kate Tolo, which began after she persistently pursued working with him. He also discussed his brain scans, noting his habit-formation brain region is in the 99th percentile.

Key takeaways

  1. Johnson recommends 5 mg of Tadalafil daily for most adults over 40, calling it one of the best longevity drugs.
  2. Johnson's sauna experiment reduced microplastics in his blood and ejaculate by 87% after 21 sessions.
  3. Johnson believes AI is 'the only thing that matters right now' and could allow the first generation to not die.
  4. Johnson's brain scan shows his habit-formation region is in the 99th percentile.

Numbers and commitments

FigureWhat it refers toTypeAt
5 mg Daily Tadalafil dose Johnson takes commitment 6:04
87% Reduction in microplastics after 21 sauna sessions metric 20:56
21 Number of sauna sessions in microplastics experiment metric 20:56
25 mg Dose of psilocybin used in his experiment metric 7:55
250 Number of biomarkers measured in psilocybin experiment metric 7:55
72% Depletion of NK cells with less than 4 hours of sleep metric 34:10
79 Current life expectancy in California metric 18:17
17 minutes Time a woman takes to be ready for sex metric 23:16
132 Number of countries with Don't Die groups metric 58:14

Chapters

  1. 0:00Introduction and breakfast
  2. 4:22Crash course on sleep
  3. 5:31Tadalafil and blood flow
  4. 7:50Psychedelics and consciousness
  5. 13:00Origin story and zeroth-principle thinking
  6. 19:58Microplastics and sauna
  7. 28:05Brain measurement and top health risks
  8. 37:34Relationship with Kate Tolo
  9. 1:00:49Diet and lifestyle details

Questions asked in this interview

12
  1. 1:00What is this? What's the point of this?
  2. 3:51Well, why'd you say, "Yeah, yeah, we're happy"?
  3. 9:09Are you the same person here, but you're in a different reality that you can see things that you couldn't see in this reality?
  4. 17:08You're the only person who's taken on this challenge. Are there other guys?
  5. 21:38Is there an optimal—anything about sex?
  6. 28:22He says that I can measure my brain. What are we measuring?
  7. 33:50... hit it home for me was if you get less than 4 hours of sleep, your NK cells, which are literally the cells that go through your body and look for cancer—that's their job, they're fighting cancer and they address it—those deplete how much?
  8. 40:31We created a little bubble between the two of us where it was safe, right?
  9. 45:25Were you wearing lip gloss that was hypnotic?
  10. 52:40Where do you stand in longevity for being, not like mindful, but they say pessimistic thoughts in your own head?
  11. 58:20Do you ever meet a guy and you're blown away by the statistics he's done on his body, where he's kind of close to you, so maybe you sprinkle a little microplastic in his smoothie?
  12. 1:03:58Do people ever try to tear you apart when you go to an interview, or no?
Host 0:04 ↗
Yeah. So, why don't you tell everyone?
Co-Host 0:05 ↗
Chuck, shut up.
Host 0:06 ↗
No, you don't think you owe people an explanation?
Co-Host 0:09 ↗
I just found out that I'm very allergic to bees.
Host 0:13 ↗
So, what happened to your foot? You got stung by—
Co-Host 0:15 ↗
Stung on the bottom of my foot, and for six days my foot looked like the Nutty Professor. And now it's slowly starting to come back, and I'm starting to get feeling in it again. But apparently I have to carry an EpiPen now.
Host 0:26 ↗
Oh my god.
Co-Host 0:27 ↗
I know.
Host 0:28 ↗
Did you look like Mr. Klump?
Co-Host 0:29 ↗
Yeah, I looked like Sherman Klump.
Host 0:31 ↗
Should I be carrying an EpiPen? Just—
Co-Host 0:34 ↗
Yeah, as his friend.
Host 0:35 ↗
Should be dressed cool today. Now, I don't know if you realize this, but your buttons are all one off.
Co-Host 0:41 ↗
Oh, are they? Fully one off.
Host 0:44 ↗
Yeah.
Co-Host 0:44 ↗
Wow. But it might look better.
Host 0:46 ↗
Yeah, it kind of looks cool. Actually, I think you like it.
Co-Host 0:49 ↗
Yeah. I think it looks way better.
Kate Tolo 0:50 ↗
Hey guys.
Bryan Johnson 0:51 ↗
Hey.
Host 0:53 ↗
How's it going? Good to see you.
Co-Host 0:55 ↗
Hand. I can't, I can't, I can't. My back, my—
Host 0:57 ↗
Okay. I got it.
Co-Host 0:59 ↗
You're a martyr.
Host 1:00 ↗
I am a prisoner of this world that I built. What is this? What's the point of this?
Kate Tolo 1:03 ↗
The world is just toxic.
Bryan Johnson 1:07 ↗
I wrote some soft porn of seducing Kate.
Host 1:10 ↗
What?
Bryan Johnson 1:11 ↗
We now have like godlike abilities.
Host 1:14 ↗
Sexual tension. I see him smiling when she came out. You're like, "Hello. Welcome."
Co-Host 1:21 ↗
Oh my god. No. No, I just want to let you guys know that they haven't cleaned the air filters here in about 15 years.
Host 1:31 ↗
And we got we have a very low level of anthrax pumping through the—
Co-Host 1:36 ↗
Throughout the house.
Host 1:36 ↗
The air.
Kate Tolo 1:37 ↗
Did we bring our—
Bryan Johnson 1:38 ↗
Yeah, I think I hope so. We might be able to actually prove that's true.
Kate Tolo 1:41 ↗
Yeah, I hope it's—
Host 1:42 ↗
I would like to know. I think—
Kate Tolo 1:43 ↗
Yeah, I think I would like to know.
Host 1:45 ↗
Can you prove everything? We brought our gadgets.
Bryan Johnson 1:48 ↗
We can prove a lot.
Host 1:48 ↗
Wow. What do we got going on? Look, did you make that?
Bryan Johnson 1:54 ↗
No.
Host 1:54 ↗
Who did?
Co-Host 1:55 ↗
What is this? What's the point of this? What's going on? I don't understand what's going on.
Kate Tolo 2:00 ↗
We brought you food for breakfast.
Bryan Johnson 2:04 ↗
We brought you guys food. We brought some biological age measurement devices.
Host 2:08 ↗
So, I don't want to die. I don't.
Bryan Johnson 2:12 ↗
That's a good attitude.
Host 2:13 ↗
I don't want to die. I actually every day I feel like you guys maximize for longevity. I maximize for fun every day. Like every day I want to be like if I didn't have a great day, cuz what if I die tomorrow? Like I can't restrict myself.
Co-Host 2:29 ↗
I feel like if there's two people that are really giving in to their every whim—no, not you. I'm saying unlike them. You mean you're more like if we are giving in to our every impulse as far as like—
Host 2:39 ↗
Oh, I thought you were saying someone who wakes up and has the best day and most productive day. No, I'm saying in the way that you're optimizing every single health thing you can do, we are totally ignoring that to such a—especially me. Maybe not as much as you.
Co-Host 2:53 ↗
You too.
Host 2:54 ↗
Yes.
Bryan Johnson 2:54 ↗
You too like to make the most of life.
Host 2:56 ↗
Do you guys drink wine?
Bryan Johnson 2:58 ↗
No.
Kate Tolo 2:59 ↗
No.
Host 2:59 ↗
Do you guys eat pasta?
Bryan Johnson 3:02 ↗
No.
Host 3:05 ↗
Do you guys eat sugar?
Bryan Johnson 3:06 ↗
No.
Kate Tolo 3:06 ↗
No.
Host 3:07 ↗
Okay. So, what do you eat? What are you doing every day? What?
Bryan Johnson 3:08 ↗
Oh, yeah. We brought you actually So, we brought you a full meal.
Kate Tolo 3:11 ↗
Yeah.
Host 3:13 ↗
Okay. This looks incredible.
Kate Tolo 3:14 ↗
Yeah. And then this also is incredible.
Host 3:16 ↗
What's in that? What is that one?
Kate Tolo 3:18 ↗
This is macadamia nuts, walnuts, flax seed, pomegranate juice, blueberries, raspberries, blackberries, and yeah.
Host 3:27 ↗
You're naming all my— Well, what's the water substance?
Kate Tolo 3:30 ↗
Yeah. Are you allergic to anything? Are you doing—
Bryan Johnson 3:32 ↗
Macadamia nut milk.
Host 3:33 ↗
Oh, so it's macadamia nut.
Kate Tolo 3:34 ↗
Yeah, we take mac nuts and we actually blend it. Yeah.
Host 3:37 ↗
I need to know more about the way that you guys eat and live. What do you indulge in? Do you indulge in nothing?
Bryan Johnson 3:46 ↗
No. Yeah, nothing.
Co-Host 3:47 ↗
The whole premise is no indulge.
Kate Tolo 3:48 ↗
Berries.
Bryan Johnson 3:49 ↗
Yeah, we're happy.
Host 3:51 ↗
Well, why'd you say, "Yeah, yeah, we're happy"?
Bryan Johnson 3:52 ↗
Because no matter what I say, no one's going to believe if I say, "Yeah, I'm happy."
Host 3:56 ↗
You seem happy, and you guys are glowing. I mean, both of your skin is enough for me to give up everything except wine in my life and follow your path.
Bryan Johnson 4:04 ↗
I like that.
Host 4:05 ↗
That's good. I feel like they can—
Kate Tolo 4:07 ↗
Yeah. Oh my god. Okay, let's taste this.
Host 4:09 ↗
It's too much, Dave. The texture is not going to work.
Co-Host 4:11 ↗
It's not going to work. Yeah, I can hear that.
Kate Tolo 4:13 ↗
Do it for our show.
Co-Host 4:14 ↗
I like what I'm doing for the show.
Kate Tolo 4:16 ↗
Do it for the world.
Co-Host 4:18 ↗
I like what I'm doing for the world. I'm being myself for your future kids.
Host 4:21 ↗
Question.
Bryan Johnson 4:22 ↗
Yes.
Host 4:22 ↗
If someone was going to change their life tomorrow, give us a crash course in like two minutes on—
Co-Host 4:27 ↗
Well, it could be longer. Take two hours.
Bryan Johnson 4:33 ↗
Okay. Here's a two-minute crash course. People get overwhelmed, so you can't give them more than one thing to do.
Host 4:39 ↗
Yeah, it's like too much.
Bryan Johnson 4:41 ↗
And so the thing we tell people to do is lower your heart rate before bed. Here's what makes your heart rate elevated before bed: it's food, screens, alcohol, weed, anxiety, work, scrolling—
Kate Tolo 5:01 ↗
TV watching, blue light.
Host 5:02 ↗
What else is there though?
Bryan Johnson 5:03 ↗
And fights.
Host 5:05 ↗
A lot of the things that you named sound like every night.
Bryan Johnson 5:08 ↗
Yeah, exactly. That's why it's so tricky. So when you go through the list of like, "Okay, so this food is good for you," and people are like, "Great, but it's so hard to implement." But really the crux of life is how you sleep and how you feel.
Kate Tolo 5:21 ↗
How you feel.
Bryan Johnson 5:23 ↗
How you feel. Because how you feel in life mentally—
Kate Tolo 5:25 ↗
Mentally.
Bryan Johnson 5:26 ↗
Yeah, how you feel in life mentally is based upon how you sleep.
Kate Tolo 5:28 ↗
And so everything is built around sleep.
Host 5:31 ↗
Aren't you like very pro-Cialis and stuff?
Bryan Johnson 5:34 ↗
Yeah. Every man—probably, this is not, potentially women—every man over 40 should be microdosing. Actually, men and women.
Kate Tolo 5:45 ↗
Tadalafil is a longevity drug. Women can take it.
Host 5:50 ↗
Okay. Wait, every man and woman should do what?
Kate Tolo 5:51 ↗
Low dosing Tadalafil. There's less evidence for women, but the mechanism is the same, so it should translate. Blood flow.
Bryan Johnson 6:00 ↗
Yeah, it basically helps your blood flow throughout the body.
Host 6:03 ↗
So you take it every day?
Bryan Johnson 6:04 ↗
Yeah, 5 mg every day. It probably is one of the very best longevity drugs that so few people are doing it. Everybody should be doing it.
Host 6:11 ↗
So everybody should be taking penis pills?
Bryan Johnson 6:13 ↗
This is not medical advice. The evidence is men over 40. That's where the bigger studies are, but it's clearly applicable to men in their 30s, too. It's not clear whether men in their 20s would do well; that's not clear. Women it would be applicable. So it's not clear at what point and for whom, but generally speaking, it's one of the best longevity drugs in the world.
Kate Tolo 6:34 ↗
What is the point of having good blood flow? Do you know that men with ED, erectile dysfunction, that can predict things like cardiac events by 3 to 5 years?
Host 6:45 ↗
Wow.
Kate Tolo 6:46 ↗
Because the penis has smaller blood vessels than the rest of the body, and so it's the first thing to show up when problems happen. So it's all about blood flow. That's why it should work for women just as well as it works for men, because we have blood vessels too.
Bryan Johnson 6:59 ↗
That's why men should measure their nighttime erections to see if they're—
Host 7:03 ↗
How much fluctuation is there in a boner?
Bryan Johnson 7:05 ↗
A lot.
Kate Tolo 7:06 ↗
Lots.
Host 7:06 ↗
As you get older?
Bryan Johnson 7:08 ↗
Yeah. A healthy 20-year-old will have nighttime erections in the range of around 2 and 1/2 to 2 hours and 45 minutes per night, five erection episodes, and then each one is graded on a scale from 0 to 100.
Host 7:21 ↗
Coffee. Is that terrible? Do you guys drink coffee? My next question.
Bryan Johnson 7:23 ↗
It's good. Coffee is good.
Kate Tolo 7:26 ↗
Coffee is good.
Host 7:26 ↗
Do you drink a cup?
Bryan Johnson 7:28 ↗
Yeah, have a cup.
Kate Tolo 7:29 ↗
I don't drink any caffeine.
Host 7:30 ↗
Oh, you don't either?
Kate Tolo 7:32 ↗
I don't do caffeine. I do decaf coffee.
Host 7:33 ↗
So, you don't do caffeine?
Bryan Johnson 7:34 ↗
No.
Host 7:34 ↗
Wow. How bad is weed? Is weed bad?
Bryan Johnson 7:37 ↗
It generally does not score high on nearly anything.
Kate Tolo 7:42 ↗
Fun levels.
Bryan Johnson 7:44 ↗
Fun level scores very high.
Kate Tolo 7:46 ↗
Mushrooms. That is very relevant.
Host 7:49 ↗
What is it?
Kate Tolo 7:50 ↗
Bryan live-streamed doing psilocybin.
Host 7:52 ↗
Oh yeah, I saw something about that. Tell me about your experience. I'm interested.
Bryan Johnson 7:55 ↗
So, the goal is trying to find things that extend life. There was a study that showed that mice had their lives extended by psilocybin, the active ingredient in magic mushrooms. And so we did the world's most quantified experiment on psilocybin. We measured like 250 biomarkers on my body and my brain, and then we did three doses of 25 mg of psilocybin, and we live-streamed it.
Host 8:22 ↗
Were you scared?
Bryan Johnson 8:23 ↗
First of all, the outcome of the study is we think that psilocybin is a legitimate contender as a longevity therapy.
Kate Tolo 8:31 ↗
It's not just about tripping.
Bryan Johnson 8:33 ↗
We had evidence in terms of it was good for blood glucose, it was good for my microbiome, it was good for—we had this really long list. We were very surprised that this ancient medicine that's used in rituals and also used as a party drug was also like this hidden thing about longevity. But then I'd say what seemed real when I was in there is when you go into that world, that world is as real as this world.
Kate Tolo 9:02 ↗
Yes.
Bryan Johnson 9:03 ↗
And it feels like there's a conversation happening there just like there is happening here.
Kate Tolo 9:09 ↗
And it's a much deeper conversation, but it feels as real. So it's almost like Inception. Are you the same person here, but you're in a different reality that you can see things that you couldn't see in this reality?
Bryan Johnson 9:23 ↗
I think non-stop about existence.
Host 9:26 ↗
Yes. Me too.
Bryan Johnson 9:27 ↗
Consciousness.
Host 9:28 ↗
Yes. Like I can't stop thinking about it.
Bryan Johnson 9:30 ↗
So when I go there, the thing that seemed clear to me is we are in this epic contest for intelligent life. We are conscious on this planet. We are giving birth to artificial intelligence. It's becoming very powerful and it's increasing at a speed that we can't quite comprehend, and this moment is just epic beyond our capacity to understand.
Host 9:54 ↗
That makes sense.
Bryan Johnson 9:55 ↗
We don't understand how precious our existence is. We live life, and we live until our 70s and we die. So we YOLO our way to optimize how I feel and what I want to get done and our power, status, wealth games. But when you're in that world, it just feels like there's this game being played of epic proportions.
Kate Tolo 10:15 ↗
Also Bryan, a couple of months later, live-streamed doing 5-MeO-DMT.
Host 10:20 ↗
Okay. And then what's the deal with that?
Bryan Johnson 10:21 ↗
That is the strongest psychedelic on planet Earth.
Host 10:26 ↗
Was it similar to the first experience or totally different?
Bryan Johnson 10:28 ↗
Totally different.
Host 10:29 ↗
What happened?
Bryan Johnson 10:30 ↗
It is the crown jewel of conscious existence. I cannot put into words what it's like.
Host 10:38 ↗
Try.
Bryan Johnson 10:38 ↗
It's not possible. You experience raw consciousness. It leaves you absolutely stunned. Honestly, I would say I feel like it was the biggest accomplishment of my entire life because when you get in there—so I wore the brain interface, and what happens is your prefrontal cortex wants to be in control of your narrative of who you are.
Kate Tolo 11:04 ↗
Like you are you.
Bryan Johnson 11:06 ↗
Yeah, you are you, I am me, and we have this barrier between us.
Kate Tolo 11:09 ↗
And this drug, or this psychedelic, basically blurs it. And then what it does is it basically says you need to release control.
Bryan Johnson 11:18 ↗
So you need to say yes to existence so deeply, like just yes and keep on going down. And at the same time—
Kate Tolo 11:27 ↗
You're on the verge of losing your mind.
Bryan Johnson 11:29 ↗
Yes.
Host 11:30 ↗
The panic is so— I hate panic though. I hate it.
Kate Tolo 11:34 ↗
It'd be a good exercise.
Host 11:35 ↗
How does this work for you? Cuz you're a man who wants full control of everything.
Bryan Johnson 11:39 ↗
Not really.
Host 11:39 ↗
Yeah, I think you control every part of your entire life.
Kate Tolo 11:41 ↗
I feel like there's a misconception about Bryan. Going into this experience, because a lot of people thrash, they scream—it's quite a horrific thing to observe someone doing this substance. I had zero fear going into it just because I know Bryan's brain. He's coming at the control thing from a perspective of having been in the throes of life and gone through so much darkness that it's actually not about control. It's about like when someone in your life dies or something tragic happens and you're really sober to every moment, and then for a week you live life where every second matters. This is his equivalent of living life where every second matters. It looks like control, but it's not.
Host 12:24 ↗
Why do you do it all? Immortality?
Bryan Johnson 12:27 ↗
Yeah. Because I think this is the biggest moment in the history of the human race where humans have always died, and now with AI, we are for the first time in the history of the human race where we may be the first generation who won't die. But it's not about immortality. It's not about a selfish desire. It's that we have the chance of being stewards and caretakers of existence, of carrying this thing forward. We're just on the verge of evolving into a new species.
Host 13:00 ↗
I like that. But what changed? You were living life as a very normal man. I've looked at your past; you were a completely normal man doing things that were probably bad for you, like having a hard job, having stresses. What made you change? What was the moment where you were like, "Oh my god, I have to change what I'm doing right now"? Or was it a thing that happened very gradually over a long period of time?
Bryan Johnson 13:24 ↗
When I was 21, I decided I was going to become an entrepreneur, make a whole bunch of money, and then try to do something useful in the world. It took me 14 years. I got there, I sold my company, and we made a couple hundred million dollars. And then it was this question of what do you do?
Host 13:39 ↗
Should we switch to the couch?
Kate Tolo 13:41 ↗
You can go to the couch.
Host 13:42 ↗
Let's do that.
Co-Host 13:43 ↗
I'll sit on the floor. Do you have seats that you always sit in?
Kate Tolo 13:46 ↗
We do have seats we always sit in.
Host 13:47 ↗
This couch is soft.
Kate Tolo 13:48 ↗
It's got lots of forever chemicals in it, though.
Host 13:52 ↗
Okay. So, when you describe this different species of humanity and you say AI is the thing that's allowing us to get to that, are you envisioning AI allowing us to be smart enough to preserve ourselves, or are you imagining some sort of hybrid machine-based human combined organism?
Bryan Johnson 14:15 ↗
Yeah, no one knows.
Host 14:17 ↗
A good question.
Co-Host 14:18 ↗
Okay, he deviated us from the question.
Host 14:24 ↗
Well, my question was so good that he has no idea what the answer is.
Co-Host 14:28 ↗
No, you were explaining why you did it. You were 21 years old, you decided you wanted to make a lot of money to do something good for the world. It took you 16 years to do, and then you're there and you got it. What happened then? Walk me through.
Bryan Johnson 14:43 ↗
Then it was a question of, okay, what do you do? Deciding what to do is very hard because it takes 10 years to start anything and get to the starting line, right? It takes a long time to get momentum in doing something, so I wanted to choose carefully. I did two things. One is I got a bunch of friends together. I held like 10 dinners across the country, and I would ask them this question: "Imagine we're in 2050, the world is amazing, and we're looking back on 2016. What did we do in 2016 that made the world in 2050 amazing?" People would say the same things in every dinner. Humans repeat what they hear; they're working on similar things, like there's a zeitgeist. So after the third, I was like, "Okay, I see the pattern. Everyone's saying the same things. So I'm going to make myself a challenge. I'm going to draw a box, I'm going to put all the ideas inside the box, and I can't do anything inside the box. It's got to be outside the box."
So that's what I call zeroth-principle thinking: you can't do anything that you're aware of or that others are aware of. And then I did the second thought experiment where I imagined being present in the year 2500, a few hundred years into the future.
Host 15:48 ↗
Smart.
Bryan Johnson 15:48 ↗
And whoever is there—whether it's humans or AI or some combination—they're conversing in this thought experiment and they're looking back at us and they say, "We're so grateful for Homo sapiens in the early 21st century because they did blank that allowed intelligence to thrive in this part of the galaxy." Fill in the blank.
Host 16:10 ↗
Measured their boners at night.
Co-Host 16:12 ↗
Can I tell you about a time I was scammed?
Host 16:14 ↗
Yeah.
Co-Host 16:14 ↗
New York City. A man put headphones on my head. He said, "Do you like this?" I said, "Yeah." He said, "What's your name?" And I said, "Dave." He started signing the CD to Dave. I said, "What do you—" He said, "You said you liked it." And then I paid him $10. So, I was emasculated in front of my ex-girlfriend.
Bryan Johnson 16:26 ↗
That's a good little technique he had.
Co-Host 16:31 ↗
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Host 16:35 ↗
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Co-Host 16:35 ↗
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Host 17:08 ↗
It is crazy. You're the only person who's taken on this challenge. Are there other guys?
Bryan Johnson 17:13 ↗
It's a huge challenge. It's a huge undertaking.
Host 17:14 ↗
There's no other man like you.
Co-Host 17:18 ↗
We need some more sample size, right? You're just one man.
Kate Tolo 17:24 ↗
Most measured person in human history.
Co-Host 17:27 ↗
Can't anomalies exist in life and science?
Bryan Johnson 17:30 ↗
Certainly. There's obvious limitations on it's just one person, it's one body. People's bodies are different. What we're really trying to accomplish is establish a new philosophy, a new ideology, a new religion, a new community, like a new all things that basically this is a demarcation where before this point humans died.
Kate Tolo 17:52 ↗
Yeah.
Bryan Johnson 17:53 ↗
After this point, humans have an extending lifespan. We just don't know how long and how well we can live.
Host 17:58 ↗
So what would the 21st century say? They say Homo sapiens in the early 21st century gave birth to superintelligence and they figured out they would no longer die.
Co-Host 18:10 ↗
But there's a difference between no longer die and live for a really, really long time.
Bryan Johnson 18:14 ↗
Mm-hmm.
Host 18:14 ↗
I'm surprised you're even reaching for immortality.
Bryan Johnson 18:17 ↗
It's not even immortality. It just means if we start extending—life expectancy is 79 right now in California. So let's say next year becomes 80 and the next year becomes 82.
Host 18:31 ↗
Why are you living in California? Is it longer other places?
Bryan Johnson 18:34 ↗
Actually, it was for the brain interface company.
Kate Tolo 18:37 ↗
Just keep going.
Bryan Johnson 18:39 ↗
So imagine then by 2030 it's 84, by 2032 it's extending further. And so now we're like, "Huh?" So it's not that we solve immortality; it's that we shift our mindset. It's like, "Wait a second, as an 80-year-old, I can have the same cognitive capacity and physical capacity as a 25-year-old." And so when that happens, humanity will be like, "Wait, I have to rethink stuff." And so that's the beginning of the psychological consideration.
Host 19:11 ↗
You have to get everybody kind of on board to understand the long-term goal.
Co-Host 19:14 ↗
That's not even hard. Everyone knows that in the '30s they were dying at 40, and now they're 80. And I'm sure in 100 years they'll be 150, and what you're doing would make you like 3,000 or whatever. But immortality, would you say, is a complete impossibility?
Bryan Johnson 19:30 ↗
We don't know anything. What's cool about this is that when you ask somebody if they want to live forever, they'll say no because most people resist that. But then if you say, "Do you want to live for tomorrow?" everybody says yes because you have things going on tomorrow. Wanting to live for tomorrow and wanting to live forever are the same idea.
Host 19:57 ↗
I agree.
Bryan Johnson 19:57 ↗
There's no difference.
Host 19:58 ↗
I read a thing that you did—I don't know if it's true—about how you rid your body of almost all of its microplastics. Is that true?
Bryan Johnson 20:09 ↗
Yeah.
Host 20:10 ↗
What type of cutting board do you use?
Bryan Johnson 20:12 ↗
Wood.
Kate Tolo 20:13 ↗
Wood.
Bryan Johnson 20:13 ↗
Yeah, we try to purge the house of plastics. We did this experiment where we were trying to look at microplastics. It's a big deal. So we measured microplastics in my blood and also in my ejaculate because there was a study that showed that 100% of men had microplastics in their ejaculate and their testicles.
Kate Tolo 20:36 ↗
And that's probably related to fertility.
Bryan Johnson 20:38 ↗
Yeah, it's just a bad thing to have in there.
Host 20:42 ↗
I have the same device. Turn that around.
Kate Tolo 20:47 ↗
I have the exact same one at home. Yep, same one.
Host 20:50 ↗
How valuable?
Co-Host 20:51 ↗
Wait, you guys, I just want to hear—you just finished the microplastic thing.
Bryan Johnson 20:56 ↗
After doing 21 sessions of sauna, my microplastic levels in my blood and ejaculate lowered by 87%.
Host 21:04 ↗
Sweats it out.
Bryan Johnson 21:05 ↗
It was the first in-human demonstration of it. We don't know if it was from the sauna, from the heat—we don't know. We just know that it lowered. So every man has to immediately—why aren't there national PSAs about this? Get into the sauna right now.
Co-Host 21:23 ↗
Too small of a sample size, I'd say.
Bryan Johnson 21:25 ↗
I mean, but people should do the experiment to see if they replicate. There should definitely be a follow-on, because if it's truly effective, it's a big deal.
Host 21:34 ↗
Does sex hold value?
Co-Host 21:36 ↗
Yeah, if you do it in the heat.
Host 21:38 ↗
Is there an optimal—anything about sex?
Bryan Johnson 21:42 ↗
As much sex as you can have. Yeah.
Host 21:45 ↗
How could it be? Your heart rate.
Bryan Johnson 21:46 ↗
The only thing that passes the list is sex. Sex at any time is great.
Host 21:51 ↗
Really? So you're okay with sex past your bedtime?
Bryan Johnson 21:54 ↗
Yeah.
Host 21:54 ↗
Why? Sex at any time is great? Why? How come?
Bryan Johnson 21:57 ↗
Because sex is very hard to come by. It's very hard to find the right moment, the right timing, the right situation. So when it presents itself—
Host 22:04 ↗
Tell me about it.
Bryan Johnson 22:05 ↗
Take it.
Kate Tolo 22:06 ↗
Yeah, and it's just so good for connection.
Host 22:08 ↗
What does that mean? I'm joking.
Co-Host 22:10 ↗
How often do you think the average couple should be having sex?
Kate Tolo 22:15 ↗
As much as they can.
Host 22:16 ↗
You're saying how many times—no, how many days out of the week?
Bryan Johnson 22:20 ↗
Seven.
Kate Tolo 22:21 ↗
Seven.
Bryan Johnson 22:22 ↗
I don't know if there's an upper bound.
Host 22:24 ↗
He's saying as much as humanly possible.
Kate Tolo 22:25 ↗
Yes. Okay, so here's a few things we've done. For example, when couples have sex—
Host 22:33 ↗
You studied this with yourselves.
Co-Host 22:34 ↗
You're not getting Uncomfortable Partner of the Year award. This doesn't make you feel uncomfortable. All right, tell us about—
Bryan Johnson 22:43 ↗
I really believe that taboo things should be—why can't we talk about this?
Host 22:48 ↗
Let's talk about it.
Kate Tolo 22:49 ↗
Let's all talk about another bottle of olive oil. Let's talk about it. Okay. Best partner of the year award because Bryan just went deep into the research on how to have sex, and then he brought me information that I didn't even know about myself.
Host 23:03 ↗
Oh my god. Tell us everything. Were you bad at sex before?
Bryan Johnson 23:07 ↗
I just didn't know. Was I bad at sex before?
Kate Tolo 23:11 ↗
He was always great at sex. This is like next level.
Host 23:15 ↗
Tell everybody.
Kate Tolo 23:16 ↗
Okay. In the moment where it's like, okay, you're together and it's like this might happen, a man is ready to go in 30 seconds, right? A woman takes around 17 minutes to be ready.
Host 23:30 ↗
I could tell you that. I call it the transition.
Kate Tolo 23:32 ↗
Yes, you have to like mentally—women tent. The cervix actually retreats.
Host 23:40 ↗
Yeah.
Kate Tolo 23:40 ↗
It tents, like it goes away. It retreats to allow room for penetration. It's not just like us getting warmed up; it's literally mechanical. So for 17 minutes—
Host 23:53 ↗
Literally.
Co-Host 23:53 ↗
Are you saying you should be flirting for 17 minutes or you should be, you know, foreplay?
Kate Tolo 23:57 ↗
Foreplay. Basically, once that tenting process, once that clock starts, the woman starts—she'll tent. So even if a woman's wet, it does not mean she's ready. It's part of the process. Then the cervix actually mechanically moves to make room for penetration. And so if you have sex before that, it'll hurt. Then other things—that's a mechanical process; a woman can't just be like, "I'm going to tent in 3 minutes." It's a process that happens.
Host 24:25 ↗
And it's always 17—like 17-ish, 17 to 20?
Bryan Johnson 24:29 ↗
And then there's also nerve fibers in the body. So if you're touching your partner, if you move fast, the body registers that as, "Oh, I feel a sensation of being touched." If you move below 3 cm per second, it communicates to a certain nerve fiber that that's intimate. So the speed of your touch—
Kate Tolo 24:52 ↗
Slow it down.
Host 24:53 ↗
You've always been good at that.
Co-Host 24:55 ↗
I know. It's my best.
Host 24:56 ↗
Yeah, she always says that he's a great toucher.
Co-Host 25:01 ↗
Ever since I first started kissing and doing anything with women, my reputation in sixth grade was like he's the best at feeling boobs.
Host 25:09 ↗
Not in a bad way.
Co-Host 25:16 ↗
He has a very good touch.
Host 25:18 ↗
Have an intuitive, amazing—very good.
Bryan Johnson 25:21 ↗
17 minutes slow touch. The nerve fibers—yes, you'll have feedback when you do that. The nerve fibers will then—that's why you get goosebumps, because the hairs stand up. And so you get this mechanical feedback from the body of you've done the right speed, you've got the feedback mechanism, and now that tenting process is commencing. So then it's go time.
Host 25:43 ↗
What about once it starts? I mean—
Co-Host 25:44 ↗
Wait, tell us some more. We have 16 minutes to go. I'd like every detail that you care to give.
Kate Tolo 25:50 ↗
The nipple is connected to the clitoris.
Bryan Johnson 25:53 ↗
So when you do nipple play, it's essentially the same as clitoris play.
Host 25:57 ↗
How could that be?
Bryan Johnson 25:58 ↗
The same wiring.
Host 26:00 ↗
Okay, let me ask you this. I heard a rumor growing up that the male nipple was just as sensitive as the female nipple. Is that true?
Bryan Johnson 26:06 ↗
Well, I don't know. Mine's pretty sensitive.
Host 26:08 ↗
If this is what that feels like, it sucks being you guys.
Co-Host 26:12 ↗
You just don't have sensitive nipples.
Host 26:13 ↗
And I heard that males and females have the same nipple sensitivity.
Kate Tolo 26:17 ↗
Women can have different sensitivity on their arm. Keep going.
Host 26:20 ↗
Okay, so nipples are the shit.
Bryan Johnson 26:22 ↗
Yeah, so you do that in that 17 minutes. It is the shit. And so, but then of course you want to have the right pressure. You don't want to make it—so whatever the person's preference is.
Host 26:31 ↗
Yep. Know your partner.
Kate Tolo 26:32 ↗
What else was on our—I can't remember.
Host 26:35 ↗
What about speed of—once it's in, is this better than this or we don't know?
Bryan Johnson 26:41 ↗
We should do more research and put out a book or something.
Host 26:45 ↗
Yeah, we should do more research.
Bryan Johnson 26:46 ↗
So there is a lot of unknown. When I learned this, I wrote some soft porn.
Host 26:54 ↗
What?
Bryan Johnson 26:54 ↗
Of basically seducing Kate.
Kate Tolo 26:59 ↗
Yeah, you took that long. No, that wasn't his tweet. It was a different long thing.
Host 27:05 ↗
If tomorrow three other guys went on social media—doesn't have to be us, but it could be; not us, three other guys—and they started seeking the same thing and posting all about it, and they were really dynamic and they had good personalities and they reached stardom, would you be annoyed or would you be happy to have more sets of data for humanity?
Bryan Johnson 27:33 ↗
Happy. People call all the time and they're like, "I'm going to beat you." Great, I'll help you. The goal is that others beat me. If you think about the 21st century, all of the small-mindedness of wanting power, wealth, and status as an individual doesn't matter. We're playing this epic game of conscious existence. So it's trying to move the species toward—we want society to change. We want it to move into this new era of evolving.
Host 28:05 ↗
I wanted to know, if you had to boil it down right now, the 10 worst things you can do for your body right now. That's just the first question.
Bryan Johnson 28:15 ↗
Can I measure my brain while he asks questions?
Host 28:17 ↗
Oh, yeah, yeah.
Bryan Johnson 28:19 ↗
Measure your brain. I need to set it up.
Host 28:22 ↗
It's going to take you a second. He says that I can measure my brain. What are we measuring?
Bryan Johnson 28:26 ↗
His age.
Host 28:27 ↗
Oh, his age.
Bryan Johnson 28:28 ↗
Yeah. So, it looks at your patterns and it'll give you an age. It will give you a number.
Host 28:32 ↗
But don't you want to be older and wiser? Don't you want your brain to live a long time, but you want your brain to be full of wise knowledge?
Bryan Johnson 28:39 ↗
It's not necessarily the content of what's happening in the brain, but more like the activity, like how robust, how quickly are the patterns happening.
Host 28:46 ↗
Neuroplasticity.
Bryan Johnson 28:47 ↗
Yeah. You know how you talk to someone who's older and they're slower?
Host 28:53 ↗
Oh, you got a fast brain.
Co-Host 28:54 ↗
I do have a fast brain, but I smoked a little bit of weed.
Kate Tolo 29:00 ↗
That probably will have some impact.
Host 29:04 ↗
You can always retest again.
Bryan Johnson 29:05 ↗
Yeah, why don't you?
Co-Host 29:06 ↗
So, if there's any negativity, it's all on my—the weed can make me seem—
Kate Tolo 29:09 ↗
It'll take me like 5 minutes to set up.
Host 29:12 ↗
Would you set up while you're setting it up?
Bryan Johnson 29:15 ↗
Do you want to—we can all go over there.
Host 29:16 ↗
Yeah, let's go over there.
Bryan Johnson 29:17 ↗
Okay.
Host 29:17 ↗
A part of me thinks it could just hurt my ego.
Co-Host 29:21 ↗
What about your face thing? Don't you want to see that?
Host 29:23 ↗
I'm scared of that.
Co-Host 29:24 ↗
I don't think they brought the face thing.
Host 29:25 ↗
I don't want to know.
Kate Tolo 29:26 ↗
We'll check the air in here while we're waiting.
Host 29:30 ↗
Is that good?
Kate Tolo 29:31 ↗
This is the best thing I've ever had.
Host 29:32 ↗
So, do you guys avoid traveling because there's so much—it's probably full of microplastics.
Co-Host 29:37 ↗
Don't mind me if I just sneak out and do a little live shopping thanks to eBay Live. You probably don't know about eBay Live cuz you probably just know eBay, and where there's a date and you've got to bid by that date. Not anymore. I mean, they probably still have that version, but I just go on to eBay Live and I call it how I see it. These are things that are happening real-time, live shopping that I wouldn't even think about getting. How about some cards, some unique cards, trading card type stuff, because they've got vintage things. They have Rolexes, which is above my pay grade, but I'm just saying there's a wide variety of things that when you go on eBay Live, you can get a Yoda action figure sealed. That's my dog. I've always loved Yoda; I love his shape and I love his physical size. But it's just fun. Sometimes you don't want to go inside and learn more about how much time you have left; you'd rather live in the moment. But every good thing comes to an end. It's fun in there, too.
Kate Tolo 30:33 ↗
Okay, we're ready. So what's going to happen is it's going to play music and you're just going to watch the screen.
Bryan Johnson 30:44 ↗
We are in this epic contest for intelligent life.
Host 30:51 ↗
I love how seriously Dave's taking this.
Kate Tolo 30:54 ↗
You need to release control.
Bryan Johnson 30:59 ↗
Grip strength is an incredible predictor of age and longevity.

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APA

Johnson, B. (2026, August 25). The Bryan Johnson & Kate Tolo Episode | Friends Keep Secrets [Interview transcript]. Friends Keep Secrets and 4 more. CEOInterviews.AI. https://ceointerviews.ai/interview/1265870/

MLA

Bryan Johnson. "The Bryan Johnson & Kate Tolo Episode | Friends Keep Secrets." Friends Keep Secrets and 4 more, 25 Aug. 2026. Transcript, CEOInterviews.AI, https://ceointerviews.ai/interview/1265870/.

BibTeX
@misc{johnson2026_1265870,
  author       = {Bryan Johnson},
  title        = {The Bryan Johnson \& Kate Tolo Episode | Friends Keep Secrets},
  howpublished = {Interview transcript, Friends Keep Secrets and 4 more. CEOInterviews.AI},
  year         = {2026},
  month        = {aug},
  url          = {https://ceointerviews.ai/interview/1265870/},
  note         = {Speaker-attributed transcript with timestamps}
}