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Martine Rothblatt
Founder, Chairman & Chief Executive Officer, UNITED THERAPEUTICS CORP

InCharge with DVF | Podcast- Martine Rothblatt: Finding Opportunity in the Corridor if Indifference

📅 May 13, 2026 Perennial Innovator: Dr. Martine Rothblatt 37 MIN 72 SEGMENTS · 3 SPEAKERS
Diane Von Furstenberg speaks with Martine Rothblatt Not only did Martine Rothblatt co-found Sirius XM, but she also then sold her stake in the company to create the medicine that would save her daughter’s life. On this episode of InCharge with DVF, Martine shares her captivating journey and reveals how she innovated everything from streamed radio and organ transplant technology, to the misguided perceptions about the transgender community. Determined, brave, and certainly in charge, Martine opens up about the challenges she has endured and how they ultimately propelled her forward. Listen in...

What Martine Rothblatt said

Written from the verified transcript and checked against it. Every figure links to the moment it was said.

Martine Rothblatt, founder and CEO of United Therapeutics, discussed her journey from satellite communications to biotechnology. She described growing cells to create transplantable organs, aiming for FDA approval in the 2020s. Rothblatt detailed her experience as a transgender woman, feeling like a 'stranger in a strange land' and calculating the risks of coming out. She recounted her first feeling of being in charge at age 15, when she left home over a hair ultimatum and supported herself. Rothblatt identified her mother as her biggest influence and described her father's public acceptance after her transition. She discussed a failed clinical trial for a pulmonary hypertension medicine, reframing it as scientific progress. She explained her strategy of pursuing 'corridors of indifference,' like rare diseases and satellite radio, and detailed her early inventions, including Direct TV, PanAmSat, and GPS. Rothblatt concluded with the story of her daughter Genesis's diagnosis and her founding of United Therapeutics to develop a treatment.

Key takeaways

  1. Rothblatt aims to create an unlimited supply of transplantable organs, with FDA approval expected sometime in the 2020s.
  2. Rothblatt funded five researchers at $1 million per year each to find a cure for pulmonary hypertension.
  3. Her daughter Genesis, diagnosed at age six, is now over 30 and works at United Therapeutics.
  4. The medicine developed for pulmonary hypertension has produced over $1 billion in annual revenues for more than a decade.

Numbers and commitments

FigureWhat it refers toTypeAt
2020s Timeline for FDA approval of transplantable organs timeline 2:35
$1 million a year Annual funding per researcher for pulmonary hypertension research commitment 24:30
over $1 billion a year Annual revenues from pulmonary hypertension medicine metric 24:30
over 30 Age of daughter Genesis at time of interview metric 33:02
50 times more Increase in people alive with pulmonary hypertension since start metric 33:02
1974 Year of epiphany about satellite communications in Seychelles timeline 24:30
30 years old Age when launching Sirius XM metric 26:38

Chapters

  1. 0:00Growing cells for transplantable organs
  2. 6:10Identity as a transgender woman
  3. 12:47First feeling of being in charge
  4. 15:01Family influence and acceptance
  5. 17:48Dealing with failure in clinical trials
  6. 20:45Corridors of indifference strategy
  7. 23:04Early inventions in satellite communications
  8. 27:39Daughter's diagnosis and founding United Therapeutics

Questions asked in this interview

12
  1. 2:33So what do you do with cells?
  2. 3:24I mean how do you define yourself? Who are you?
  3. 7:02But did it scare you at first?
  4. 7:38But did you actually know that clearly?
  5. 8:13You know because you know how I always say the most important relationship in life is the one you have with yourselves and your mantra is be fearless, right?
  6. 14:54Biggest influence on you. Your father or your mother?
  7. 15:02Your mother was a comedian, right?
  8. 15:33What do you think about that?
  9. 19:41Are you a superhero? Are you a conduit?
  10. 20:16So we'll settle that you are a visionary that doesn't take no for an answer. Will you agree with that?
  11. 26:34So by then you are how old?
  12. 27:30All right. And then what happened?
Martine Rothblatt 0:00 ↗
So this extraordinary brain, it's so extraordinary, it's mystical, right? Well, this extraordinary brain was telling me 24 hours a day, Martin, you are female, you are a woman, you're a girl. Why do you keep walking around like a boy or a man?
Diane von Furstenberg 0:24 ↗
I am Diane von Furstenberg. Join me for intimate conversations with extraordinary women about the journey of life and survival. This is In Charge. I am so excited for you to meet one of the women I admire the most. Today we are in Silver Spring, Maryland to share an intimate conversation with Martine Rothblatt at United Therapeutics. Martine co-founded Sirius XM and sold her stake in the company to save her daughter's life. Martine's story is one of absolute innovation, determination, and survival. I know no one who has accomplished as much as you have both in the trajectory of your career, of your inventions, and the unbelievable journey of your life.
Martine Rothblatt 1:35 ↗
Thank you so much, D. I couldn't wish for a better person to talk with than you. And we are here in your extraordinary offices.
Diane von Furstenberg 1:46 ↗
Yes, this is part of the headquarters of United Therapeutics. These are zero-carbon footprint offices that create all of the heating, cooling, and electricity right from the exact place where we are. These are also the offices, Dion, where our company created the medicine that first saved the life of our daughter Genesis and so many other people with different life-threatening illnesses. So today, our company has been in business for over 20 years. We have this one scientist, her name's Leila, who's in charge of growing cells. She's extraordinary. Many other scientists had figured out how to grow millions of cells. She figured how to grow billions, then hundreds of billions, and now over a trillion.
So what do you do with cells?
Martine Rothblatt 2:35 ↗
We use them to create transplantable organs. It's back to the beginning that my daughter, but for the luck that I was able to come up with this medicine, the chances of her getting a transplant were one in a thousand probably. And unfortunately, every single day, hundreds of people die because they cannot get an organ transplant. By growing these cells, I'm able to grow specifically cardiac cells, lung cells, and grow organs that can then in sometime in the 2020s will be approved by the FDA to be transplanted into people. And my personal mission, my gratitude back to the universe for giving me all the good fortune it has given me is to create an unlimited supply of transplantable organs.
Diane von Furstenberg 3:24 ↗
Wow. I don't think I mean I I I it's extraordinary. I mean how do you how do you define yourself? I mean how do you define a person who has touched so many lives, saved so many lives and is now growing cells that are making transplant possible organs. I mean how do you define yourself? Who are you?
Martine Rothblatt 3:54 ↗
I define myself just as a regular person. I can tell from looking at you that you don't believe that, but it's true. I see myself as a regular person that I try to do the best that I can each day. I love life and I feel extremely fortunate. And so often times the what I do I see myself as like the end point of thousands of years of evolution of women who have given birth and died. Given birth and died. And I often ask myself if my ancestors were sitting here in front of me, what would they say to me? What would the women say who had to just give birth until they died from child birth, work in a field, starve half the time, freeze almost all the time, had nothing to look forward to other than I'm going to make another generation if all I do is make another generation. And that's gone on for millennia. Women have literally carried humanity not only in their bellies, but on their backs. And here we are in 2020 and I say to myself almost every day, what would my great-great-grandmother Jenny say to me? What would even ones that I don't even know say to me the same thing every single day?
Diane von Furstenberg 5:16 ↗
What would they say?
Martine Rothblatt 5:19 ↗
Martin, first and of all, enjoy your life. We did not suffer for countless thousands of years. My mother used to say for you to have every benefit at your beck and call and not enjoy your life. Enjoy your life.
Diane von Furstenberg 5:32 ↗
So we have established that you are a visionary, an inventor, a catalyst in a huge scale. In a huge scale. So that's incredible. And we could stop here, but there's something else that is super extraordinary about your life. So take us in that incredible journey that is so mysterious to so many of us.
Martine Rothblatt 6:10 ↗
Sure. So, I think I looked like a man and I think I was perceived as a man and I did all the things that men are supposed to do. But in the first 40 years, in my heart, in my soul, I never saw myself as a man, nor did I see myself as a little boy. I saw myself as a little girl. And as I went into teenage and beyond, then I always saw myself as a woman. So this extraordinary brain, it's so extraordinary, it's mystical, right? Well, this extraordinary brain was telling me 24 hours a day, Martin, you are female, you are a woman, you're a girl. Why do you keep walking around like a boy or a man?
Diane von Furstenberg 7:02 ↗
But did it scare you at first?
Martine Rothblatt 7:05 ↗
I I don't know. I can't say it scared me. I'd say it confused the heck out of me.
Diane von Furstenberg 7:10 ↗
Did you share it with anyone?
Martine Rothblatt 7:12 ↗
No, I didn't because I absolutely knew that it was unacceptable to share that. I was in an environment where, you know, people would, you know, regularly make fun of gay people and I didn't even really know how to explain to people that I was a woman attracted to women. I had no friend that I could trust that knowledge to.
Diane von Furstenberg 7:38 ↗
Of course. But did you actually know that clearly?
Martine Rothblatt 7:41 ↗
No. As a teenager, I did for sure.
Diane von Furstenberg 7:44 ↗
Yeah. So, you felt like a woman. You felt there was a woman inside you.
Martine Rothblatt 7:48 ↗
I knew I was a woman, right? I knew I was a gay woman, but I knew that every single person knew that I was a straight man. I mean, is that a So I I I personally, you know, I always The title of my life would have been that great book by Robert Heinlein, Stranger in a Strange Land, right? Because that's that's who I was. I was a stranger in a strange land.
Diane von Furstenberg 8:13 ↗
I know. But the thing that is different about you is that somehow everything that happens to you, which by the way I relate to very much, everything you turn into a positive. You're not saying it as a victim. You were terrified. You were afraid. You were fearful. You know because you know how I always say the most important relationship in life is the one you have with yourselves and your mantra is be fearless, right? And that's how you are in charge. So clearly you were always in charge of yourself because you knew that secret that you could not share with anyone. It was a secret that you were not shame you had no shame about it.
Martine Rothblatt 9:05 ↗
No I didn't.
Diane von Furstenberg 9:08 ↗
So you really truly accepted who you were and therefore you were always in charge.
Martine Rothblatt 9:14 ↗
I was always in charge and that's a good way to phrase it. You know, listening to you talk I realized that in a way perhaps I was calculating which has a little bit of a negative tinge to it, but it's it's accurate. I was calculating all the time that if I came out as a transgendered woman that there would be negative consequences. I would lose friends. I would lose family. I would lose job opportunities. I would lose my life. And that's what I kept calculating that. So I stayed in the closet which is not unique to me. I mean pretty much anybody before they come out that's why they don't come out is because they know there are going to be these consequences. But I never felt shame. I, you know, I loved my every part of my body and I never hated any part of my body. It was only by the time I got to my 20s and 30s that I was able to find books and literature that actually explained this to me and explained that it's just normal human variation. When I got into my 20s, I learned about these tribal people in India and other parts of the world where there's a third gender and they're accepted in their community. So this was very, you know, ratifying for me, validating for me. So when you ask who am I, I would say I am also a person that will play the odds. I never look for 100% assurance. I don't even believe that there's such a thing as 100% assurance. Every one of my businesses were risky. There was a probability of success. I've launched satellites only to see them stop working as soon as they've gotten to orbit. I've developed drugs only to see them fail in clinical trials. So I run the probabilities and I saw the probabilities were very high that I could change my body to conform with how I mentally saw myself and that in the coming of the turn of the millennium, the 1990s, there would be enough acceptance of transgendered people, perhaps I would have to move to Colorado and live a, you know, a small, quiet life. Frankly, I never imagined that I would end up being as accepted as I am in the dominant heterosexual cisgender society as I am and and be one of the highest paid women CEO in the world.
Diane von Furstenberg 11:44 ↗
Very happy about that, too. I mean, really, you truly are a woman in charge. So, when did you feel in charge the first time?
Martine Rothblatt 11:58 ↗
Nobody ever asked me that question. So, I'm That's okay. I mean, I could tell you mine if that helps. Yes.
Diane von Furstenberg 12:04 ↗
Okay. So, I felt in charge for the first time when my mother put me in a train by myself. She from Brussels to Paris and it was 5 hours or 6 hours at the time. was a long time and I was maybe 8 years old and I know I was worried but of course I would never admit that I was because I was also so proud. I was so proud and I felt in charge and I know that to this day every time I go I have I love going alone. I just feel in charge. So that's mine.
Martine Rothblatt 12:47 ↗
That's a beautiful story. Thank you for sharing it. It seems like I've felt in charge many, many times in my life. The first time I felt in charge probably was in 10th grade and my father made an ultimatum. My hair was halfway down my back and my father said, 'Either cut your hair or get out of the house. This is my house. these are my rules. Cut your hair or get out of the house.' And I said, 'Okay, I'll leave the house.' And he said, 'You're going to end up as a high school dropout and you're going to come back here begging to be let in.' And I said, 'No, I won't.' So, I walked out of the house. I got a job on Melrose Avenue and it was in a Persian carpet store where I had to like roll and unroll these carpets and customers want to look at the one at the bottom. So I had to like take, you know, 30 of these off and show that one to the customer. I rented the upstairs single apartment of an antique shop on Melrose with two other friends who they actually both were high school dropouts. And I kept going to high school and I kept going to school. I went to school. I went to work. Came home. Hung out with my friends. And finally one day I was at school and the principal's office came and said, 'Your father is here, wants to talk to you.' This was like three or four months later. He said, 'I'm really impressed with what you've done. Please come back home and you can keep your hair as long as you like.' He was a dentist. He says, 'I have a job opening in our dental lab that you'll be paid. I forgot the exact amount, but let's say like five times the minimum wage that I was getting, but you'll be working in the dental office. You'll have to cut your hair.' So, I said, 'Okay, I'll come back.' But, I felt in charge because I supported myself as a 15-year-old. And I I could have done that indefinitely.
Diane von Furstenberg 14:54 ↗
That's good. I have other questions. Biggest influence on you. Your father or your mother?
Martine Rothblatt 15:01 ↗
My mother.
Diane von Furstenberg 15:02 ↗
Your mother was a comedian, right?
Martine Rothblatt 15:05 ↗
Yes. She is a very very positive person. She will see the positive in anything.
Diane von Furstenberg 15:11 ↗
That's it. You got that?
Martine Rothblatt 15:13 ↗
She loves making people happy. Her whole purpose in life is making people happy. My father's whole purpose in life was just doing the practical things that needed to be done. Are your parents still alive?
Diane von Furstenberg 15:27 ↗
My mother is. My father passed away about 20 years ago.
Martine Rothblatt 15:31 ↗
And is your mother's super proud of you?

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Cite this transcript

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APA

Rothblatt, M. (2026, May 13). InCharge with DVF | Podcast- Martine Rothblatt: Finding Opportunity in the Corridor if Indifference [Interview transcript]. Perennial Innovator: Dr. Martine Rothblatt. CEOInterviews.AI. https://ceointerviews.ai/interview/905866/

MLA

Martine Rothblatt. "InCharge with DVF | Podcast- Martine Rothblatt: Finding Opportunity in the Corridor if Indifference." Perennial Innovator: Dr. Martine Rothblatt, 13 May. 2026. Transcript, CEOInterviews.AI, https://ceointerviews.ai/interview/905866/.

BibTeX
@misc{rothblatt2026_905866,
  author       = {Martine Rothblatt},
  title        = {InCharge with DVF | Podcast- Martine Rothblatt: Finding Opportunity in the Corridor if Indifference},
  howpublished = {Interview transcript, Perennial Innovator: Dr. Martine Rothblatt. CEOInterviews.AI},
  year         = {2026},
  month        = {may},
  url          = {https://ceointerviews.ai/interview/905866/},
  note         = {Speaker-attributed transcript with timestamps}
}