Bill Anderson2:56:41
Genetic therapies, cheoproteomics and radiopharmaceutics. We are convinced by the strength and quality of our pipeline. In particular, it is very balanced and focused given our innovation model. At the end of last year, Asundexian had shown a significant reduction of new strokes without a significantly increased risk of significant bleeding in phase three studies in the OCEANIC stroke studies. We are well positioned for stroke prevention and we are ahead of our competitors by a year. We expect approval by the end of the year or at the beginning of next year. And with that, I'd like to pass the floor to my colleague Rodrigo Zantez.
Mr. Kungler, you asked how confident we are about the product pipeline for crop science. We have every confidence in the strength and sustainability of the crop science pipeline, which is a cornerstone of our growth strategy. It is designed to address farmers' most critical needs: seeds and traits, crop protection, biologicals and digital farming solutions, while at the same time supporting profitable and resilient growth for Bayer. As part of our R&D activities, we refresh our portfolio every year with 400 to 500 new seed products and numerous crop protection registrations globally. We are also working on groundbreaking innovations. In this context, we are planning 10 blockbusters launched within the next decade, with each expected to have peak sales of more than 500 million euros, and we are making good progress. The first blockbuster, Penaxus, an innovative insecticide, has already been granted approval in Latin America and is now being launched in further markets. This will be followed by biotech versions of the Preion smart corn system and Viconic soybeans, both of which are expected to be rolled out in 2027. Our new herbicide, our fourth generation corn rootworm technology, and Intacta 5 Plus will then be launched in 2028. We expect that these blockbusters and the annual portfolio refresh will add more than 3.5 billion euros to our top line by the end of 2029. Overall, this gives us high confidence that our innovation will drive growth and margin improvement at crop science over the midterm and support sustainable value creation well into the future.
Mr. Smith, you asked about our strategy in the agriculture sector and for an update on the farm bill in the United States. Global agriculture and food systems are facing major challenges such as climate change, water scarcity and population growth. By leveraging our global leading research and development expertise and leading positions in seeds, traits, crop protection and digital farming, we are strategically addressing these challenges in a targeted manner. You also asked about the US farm bill. The legislative process has begun. Specifically, the US House of Representatives is expected to begin deliberations on the proposal starting next week. We do not wish to speculate on the future legislative timeline at this stage.
Mr. Spite, you asked whether we already see tangible and irreversible pressures from the era war on the crop science business expanding into 2027. Geopolitical tensions and ongoing trade policy uncertainties are contributing to heightened volatility across agriculture markets. We are starting to see energy prices push structural inflation across petrochemical chains, which is expected to impact intermediates, solvents, surfactants, packaging materials and formulation chemicals. While we are taking active mitigation measures in the short term, including energy hedging, diversified sourcing, alternative supply routes, and prudent inventory management to protect against abrupt disruptions, we will not be immune to the effects. In particular, we are of course closely following the increase in fertilizer costs, which is affecting both our farmer customers and the state of food security around the world. At present, we do not see any evidence of consequences that will extend into 2027. However, timing, magnitude, and persistence of the situation remain uncertain and can only be assessed on the basis of the currently known information. We are closely monitoring the situation and continuously assess both direct and indirect implications on costs, prices, and demand.
Mr. Spite, you asked whether we already see tangible and reversible pressures from the war on the crop science business extending into 2027. Geopolitical tensions and ongoing trade policy uncertainties are contributing to heightened volatility across agriculture markets. We are starting to see energy prices push structural inflation across petrochemical chains, which is expected to impact intermediates, solvents, surfactants, packaging materials and formulation chemicals. As I just mentioned, at present, we do not see any evidence of consequences that will extend into 2027. However, timing, magnitude, and persistence of the situation remain uncertain and can only be assessed on the basis of the currently known information, and we are closely monitoring all the situations to continuously assess both direct and indirect effects on costs, pricing and demand.
Mr. Closing, you asked about potential gaps in the registration procedures for crop protection products in relation to Parkinson's disease. In the course of the approval and reapproval procedures for crop protection products, regulatory authorities thoroughly review and evaluate extensive data from studies. This includes data on toxicology, ecotoxicology, effects on environment, metabolism, residues, human and environmental exposure and epidemiology. Studies on neurotoxicity, which can play a role in the development of Parkinson's disease, are also mandatory and evaluated, for example, when approving active substances. They cover both the potential neurotoxicity of the active substance after single and repeated exposure as well as reproduction toxicity effects.
Mr. Spite, you asked whether we will continue to adhere to our 5-year framework targets in crop science and whether they remain realistic and appropriate. Our sharper portfolio, optimized footprint, and increasing resilience of our earnings model make us highly confident that we will deliver on our midterm targets and that we will be able to navigate agriculture cycles with greater consistency. The execution of our 5-year framework is well on track, with 2025 already demonstrating tangible progress despite a challenging market environment. It's important to understand that this framework remains our central steering tool. It reflects current market realities, underpins discipline in execution and supports our preparations for an unprecedented number of market-shaping innovations with a clear path that encompasses sales growth, margin, and cash flow. We believe the framework continues to provide the right balance of ambition and realism for the period ahead. However, we are of course monitoring the market and the underlying conditions closely and will undertake corresponding measures as necessary.
Mr. Spite, you asked what the current geopolitical developments mean for the portfolio pruning plans in crop science and whether we would reassess the portfolio based on economic viability if market conditions were to weaken over a longer period. Portfolio pruning in crop science is a deliberate strategy to deliver on our 5-year framework and midterm financial ambitions. We have already divested multiple active ingredients and exited nearly 200 crop protection products. This allows us to prioritize investment and resources on those areas where we see sustainable profitability and innovation-driven growth. This disciplined strategy is aimed at strengthening the business's resilience throughout agriculture market cycles. As market conditions structurally change, we will continuously review the portfolio for profitability and strategic fit. We will not hesitate to take further actions where assets do not meet our economic thresholds.
Mr. Venny, you asked when the efficiency program and our innovation pipeline, including short stature corn, will lead to measurable improvements in results. The 5-year framework was launched in 2025 and we are firmly focused on execution. We have started to implement measures across the value chain, including production footprint optimization and product portfolio measures. These measures will support our profitability growth going forward. Last year we have already delivered roughly 400 million euros of efficiencies and cost savings. In addition to strengthening the operational foundation of the business, we are preparing for the launch of several blockbuster innovations in the next 10 years, all with a peak sales potential of over 500 million euros. We launched the first of the 10 blockbuster innovations already in 2025 with the insecticide Penaxus in Latin America. The Preion system, including short stature corn, was already launched in a so-called breeding version and is highly appreciated by farmers who have gained initial experience with it. It is expected to double acreage again this year and we are going towards broader commercial impact with a biotech trait introduction which is expected in 2027. Other key products, including Viconic soybeans in the United States, the herbicide Eaffoline, the fourth generation trait against corn rootworm, will begin contributing to top-line growth and margin expansion towards the end of the decade. In combination with our yearly portfolio refresh, we expect to increase our top line by 3.5 billion euros by 2029. Taken together, we expect a gradual but tangible improvement in profitability from cost and growth measures, with more pronounced effects as we move towards our midterm margin ambition for crop science.
Mr. Closing, you asked if we would be prepared to engage in dialogue about our active ingredients. We have continuously engaged in dialogue with our stakeholders for many years, including discussions with numerous NGOs. We will continue these discussions in the future because transparency is very important to us as a company. As a general principle, the safety of our products is our top priority.
Mr. Closing, you wanted to know whether we are withdrawing certain products from the market that are allegedly linked to the development of Parkinson's disease. The safety of our products is always our top priority. More than 100 regulatory authorities worldwide have approved the use of Bayer's crop protection products and active ingredients based on scientific studies. As part of the registration and re-registration process for crop protection products, regulatory authorities review and evaluate extensive data from studies. No regulatory review has ever concluded that the use of any of our registered products or active ingredients is associated with Parkinson's disease.
Mr. Arnold, you asked why you are finding less frog spawn in the wild. The European regulations for crop protection products are among the strictest in the world. EU Regulation 1107/2009 takes into account potential risks for frogs. The safety of our products is always our top priority. Our chemical and biological crop protection products are tested in early development phases in relation to their modes of action, their toxicological properties and the extent of their potential impact on nature. This ensures that the effects of our products are targeted and do not pose unacceptable risk to humans, animals or the environment.
Mr. Arnold, you asked about the safety of our products for unborn and newborn children. Our products may only be marketed if independent regulatory authorities conclude after scientific evaluation that they are safe when used properly. For this reason, all active substances and products undergo extensive toxicological testing prior to approval, including studies on reproductive and developmental toxicity. In addition, product labels contain clear instructions for use, including protective measures and restrictions on use.
Mr. Arnold, you asked what the safety recommendations are for avoiding potential pesticide-related leukemia. Before crop protection products are approved, they undergo a research and development process that lasts more than 10 years and includes extensive safety testing, including assessment of carcinogenicity, including leukemia.
Mr. Hopkins, you cited a report regarding alleged phosphorus sales in the United States and asked whether they indicate a strategic realignment of the business or establishment of another business pillar. A subsidiary of Bayer has been operating a phosphorus mine in the United States for many years now. The majority of the phosphorus produced by Bayer is used to manufacture crop protection products. This is also the business case for Bayer operating the mine. A portion of the phosphorus is, however, also sold to a limited number of third-party companies and used for various industrial purposes such as fire retardants and aviation fuel. These third-party companies are contractually prohibited from reselling elemental phosphorus for military purposes. At present, Bayer is not supplying phosphorus to the US government due to an executive order from the US president. However, the company will be obliged to respond to any potential inquiries in the future. The supply to the US government is not an additional business pillar.
So, you asked what percentage of phosphorus goes towards production of glyphosate and how much is used for military uses. As just mentioned, the lion's share of the phosphorus produced by Bayer is used to manufacture crop protection products.
Cargo, you asked why Bayer positions itself as sustainable and innovative while marketing crop protection products that are approved in some countries of the Global South but not in other regions. The fact that a crop protection product is not approved in the EU says nothing about its safety. Bayer adheres to existing and robust regulatory systems that are in place around the world to protect human health and the environment. Furthermore, countries in the Global South have different climate conditions and face challenging pest pressures. Clear examples of this include locust plagues in parts of Africa and Asia or the spread of fall armyworm in Africa. Fortunately, agriculture in the EU is not familiar with these threats. In other parts of the world, they endanger the lives of many people. Without the use of crop protection products, their food supply would be destroyed.
And with that, I pass to Julio.
Mr. M, you asked about the progress made and the perspectives regarding our Road to Billion strategy at Consumer Health. Strategically and financially, the Road to Billion strategy of our Consumer Health division is on track, even though the market environment remains challenging. At the heart of the strategy is reach. We want to reach billions of people with trusted self-care solutions. We're making step-by-step progress by reaching more consumers, strengthening our presence in digital and conventional channels, and by focusing our investments on the biggest value drivers. Our growth is increasingly volume-driven rather than primarily price-driven, and this is one of the key objectives of our Road to Billion strategy. In addition, more than 50% of our strongest brands gained market share in 2025. The Road to Billion strategy is not a short-term promise, but rather a long-term approach for growth. We're convinced that it will give many more people access to trusted healthcare solutions and bring us closer to our ambitious financial targets.
Okay. So, let's see. Mr. Vining, you asked whether Bayer will achieve the operational turnaround, and we've already made tangible progress in our operational turnaround, and we're confident about the further implementation of our strategic priorities. 2025 was a successful year for us and we met our upgraded guidance and made clear strides in containing legal risks while rapidly integrating Dynamic Shared Ownership into the company with Team Bayer on board. Our pharmaceutical strategy is clearly showing success with the performance of our newly launched products and the progress of our pipeline. And our strategy of offsetting losses from patent expirations through new product launches is clearly working, and we see growth potential starting next year. At Crop Science, we've initiated a program to increase profitability and leverage growth opportunities. So, overall, we're not finished yet, and we still have more work to do. We continue to work on containing our legal risks and delivering on all our priorities.
Mr. Verer, you asked about the emissions caused by microplastics and nanoplastics in Bayer's production processes and about specific protective measures for employees and the environment. Bayer is fully committed to compliance with all applicable laws and regulations and works diligently to implement all provisions in this area. As part of our health and safety management and also in our production processes, we adhere to the prescribed high standards in order to protect our employees and the environment.
Mr. Tumbler, Mr. Spite, you asked about potential structural adjustments once the wave of litigations has been substantially contained. Along with containing legal risks, our clear focus is to address our strategic priorities. In particular, we work toward further reducing the net debt load, boosting cash flow, and implementing our new operating model and systematically executing our divisional strategies in pharma, crop science, and consumer health. We consider all of our divisions to be attractive businesses with strong fundamentals and long-term growth potential. Nonetheless, as communicated before, we are generally open to options and must continually ensure that Bayer is the best owner of each of our businesses.
Mr. Vining, you asked whether Bayer plans to go beyond reducing its own emissions and play a leading role by enabling decarbonization through climate solutions. Bayer is pursuing a holistic climate strategy that includes positive contributions to decarbonization in addition to reducing our own carbon emissions. In agriculture in particular, our products and solutions make an important additional contribution to decarbonization. For example, we promote the adoption of climate-friendly agricultural practices and technologies such as genome editing for higher yields as well as soil management approaches like direct seeding and cover cropping. Our goal is to help customers measurably reduce greenhouse gas emissions in agricultural systems and enhance carbon sequestration.
Mr. Verer, you asked about PFAS in the supply chain and contaminated sites as well as possible liability risks. Due to their broad use, PFAS can be present at various points along the Bayer supply chain, for example, in the production process, as materials in production plants, and as intermediate products or packaging. This is a topic that affects companies worldwide and is one that Bayer is also carefully investigating and addressing. Our products and manufacturing processes follow all applicable rules and regulations and meet all safety standards. We work closely with regulatory authorities and industry partners to stay informed of the latest developments and to develop appropriate approaches to ensure compliance with future laws and regulations. If the question concerns production at Bayer Material Science, these questions must now be answered by the Covestro group, which is now an independent company.
Mr. Vernon, you asked whether Bayer was actually becoming more productive or simply smaller through the Dynamic Shared Ownership program. Overall, Dynamic Shared Ownership is aimed at making Bayer more productive. The goals of DSO are to reduce complexity, shorten decision-making paths, and move responsibilities closer to our customers, our markets, our products. The resulting cost savings and structural changes are a result of reducing layers and eliminating redundant structures rather than the primary objective. Our intent is to strategically reinvest efficiency gains into innovation, growth priorities, and competitiveness, making Bayer leaner, faster, and more focused. This will strengthen our resilience and effectiveness in our core businesses for the long term. We see ourselves well on track in this transformation and are confident that Bayer is thus well positioned for the future.
Mr. Rner, you asked about digital sovereignty regarding the use of AI, what the situation is with open-source solutions and whether we actively support startups in this context. Digital sovereignty is important to us. Among other things, we work closely not with just one but a large number of international partners. This also includes select startups that are relevant and promising for Bayer. Our focus here is on promoting innovations in our areas of healthcare and agricultural technology. Bayer has a fundamentally positive and strategically open attitude towards open-source solutions. Their use, further development and own contributions are established within the group.
Mr. Spite, you asked whether we have made adjustments to our climate and diversity policies over the past 12 months and whether the company remains committed to them. We continue to advocate on behalf of diversity and want to create a working environment in which equal opportunity and inclusion apply to everyone. This not only reflects our values, but also helps us become a stronger and more innovative company. We're a global company and will continue to work to attract high-performing diverse talent and to offer all employees an optimal working environment to unlock their full potential with us. With respect to our climate-related activities, we pursue a holistic climate strategy that not only focuses on consistently reducing our own emissions but also includes positive contributions to decarbonization. We're keeping these promises while complying with all respective applicable government laws and regulations.
Finally, Mr. Burner, you asked about the use of artificial intelligence in image videos, advertising, and promotion at Bayer. Bayer is actively involved in the use of AI in content production and media optimization. AI-powered technologies and tools are used to increase efficiency in content and media spend. This includes content generation and media optimization where in general savings of around 30% are expected. The use of AI to increase effectiveness is an important aspect of our marketing efforts.
And now I'll pass it over to my colleague Wolfgang.