About Brian Armstrong
Brian Armstrong, the co-founder and CEO of Coinbase, has been promoting the concept of an "agentic economy" where AI agents use cryptocurrency rails to transact autonomously. During Coinbase's System Update in June 2026, Armstrong announced the launch of tokenized stocks, unified global liquidity, and new AI products, including Coinbase Advisor, which he described as one of the first SEC-registered AI-powered investment advisors. He stated that Coinbase is "shipping about twice as much code year-over-year" and that the company aims to become a "primary financial account" for users, offering services such as crypto-backed mortgages and stablecoin payments. Armstrong also discussed the company's strategy of routing certain AI queries to cheaper open-source models, noting that these models are "99% cheaper" and could handle 80% of workloads.
Armstrong has continued to advocate for regulatory clarity in the U.S., arguing that it would unlock institutional capital and encourage companies to integrate crypto. He responded to criticism from JPMorgan Chase CEO Jamie Dimon, who called him "full of s--t," by stating that he remains "a little perplexed" by the personal animosity. Armstrong also expressed bullishness on Bitcoin, calling it "the new digital gold," and discussed his views on AI and longevity, including his work at the biotech company NewLimit, which he co-founded to extend human life. He stated that he is "okay with the idea of AI superseding humanity" and emphasized that founders should focus on improving the world.
Source: AI-verified profile updated from Brian Armstrong's recent appearances.
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✨ AI-enhanced transcript with speaker attribution
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Brian Armstrong0:16
Welcome everybody to the Coinbase speaker series. We've got a great guest today: Ryan Selkis. He is one of crypto's most prominent voices, going back to the very earliest days of crypto, and today he is the co-founder and CEO of Messari, a crypto research and analytics company. Previously, he was the managing director at CoinDesk, a publication that we all read a lot in the office, and he was also the first employee at a VC firm, Digital Currency Group (DCG), which many of you know. He's been writing about and investing in crypto for nearly a decade. He just published a really impressive annual report that Messari puts out; it's 165 pages, it takes about 250 hours a year to put it all together. It's an incredible read that covers a wide range of topics happening in crypto, everything from what's coming up in 2022 to the collapse of trust in institutions. We're going to talk about many of those topics in the report today. So Ryan, thank you so much for being here first of all.
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Ryan Selkis1:13
Yeah, thanks for having me. It's good to do this.
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Brian Armstrong1:15
The first time I remember your name really blew up in the crypto space and got really popular was the post you put out. You used to be pseudonymous, it sounds like before it was cool to be honest. You went under the handle Two-Bit Idiot, right? And you put out this post about Mt. Gox and the coming collapse, and then that post went viral. I remember that was the first time you'd really gotten on my radar as well. So anyway, what was going on for you in the early days like that? How did you decide to start posting pseudonymously?
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Ryan Selkis1:44
So I started my career in VC, decided pretty quickly I wanted to be on the other side of the table, and started a company when I was 25 focused on charitable payments that required IRS approval for a pretty critical component of the business. I decided to defer an offer to business school to work on it, but ultimately shuttered that business in October. So I deferred for a year, had nine or ten months in my hand, and it happened to be early in that 2013 run-up, the fall of 2013. So I had to make a decision: what am I going to do with the next 10 months, and what am I going to do with this asset that just went up six times in a matter of weeks that I kind of locked into because I bought a little bit actually on Coinbase just to start learning a bit more about Bitcoin. I went down the proverbial rabbit hole over a long weekend and realized there wasn't really anyone writing about Bitcoin full-time. Started a newsletter, started opining on the Reddit forums, that's how we got connected pseudonymously. At the time, there were probably only a couple hundred people that were either funded or actively investing or full-time in the space, and many of them were subscribers. So I ended up getting my hands on the Mt. Gox document that exposed what they were trying to salvage in terms of the $700 million hack or whatever the ultimate damage was. So I started writing out of necessity because I had 10 months on my hand and I didn't want to get another full-time job, and I decided I was excited enough about Bitcoin to take a chance and maybe pass on business school. Sure enough, that's what happened. I joined DCG later that year, helped build the core team, was running seed investing at DCG in the early days. We closed around in 2015, and then when we acquired CoinDesk, I flipped back over to the operating side. So in some way, shape, or form, I've been touching information products for close to a decade with respect to crypto from a few different seats at the same table.
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Brian Armstrong3:49
Well, you've been such an important voice in the crypto community. It's been awesome to see it develop over the years. There was this recent example back in August, I guess we put out this iconic tweet which went viral, and you said: 'I'm sick of feeling like we have to apologize for our early stage and walk on eggshells around politicians and regulators. We built a two trillion dollar financial market from scratch in less than a decade with absolutely no institutional help and active encumbrances from government.' You go on in the tweet, but I mean this really struck a chord with the community. I think it felt like we were working so hard behind the scenes to try to create a better world here, and it would be nice once in a while for someone to say thank you, but even if you can't say thank you, at least don't do no harm, right? And it always felt like there were people actively pushing back along the way about the creation of this new financial system. I mean, what sounds like that tweet just came to you in a moment of inspiration, it wasn't like some massive thought-out thing, but what was going through your head at that time when you put out that message?
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Ryan Selkis4:52
Well, I think it's probably similar to a lot of other folks, particularly those that have been around for a while. You and the early folks at Coinbase have been working on regulated financial products and financial services, adding credibility to this industry for a long time. There are dozens of others that are in our shoes. From my standpoint, Messari was born really as a bit of a policy response itself. If you think about our core information products, we're trying to reverse engineer what SEC disclosures would look like or what a good solid set of information reporting standards would look like for community-governed assets. And some of the language coming out of DC, particularly around the broker language and the infrastructure bill and the debate over that particular provision, at some point you just throw up your arms and you're frustrated getting slapped around by misinformed or downright dishonest folks in DC just because it fits their political purposes. So I think that frustration bubbled over for a lot of us, and I'm glad it did because in the 'never let a crisis go to waste' mindset, August was a pretty good rallying cry. We knew we were going to have to get active at some point, and it wasn't just going to be a straight shot to cleanly integrating into the financial system with no roadblocks put up by regulators or the state long term. So it's not so much that this broker language got passed and we ultimately lost the battle; I think as a catalyzing event, it was much more powerful long-term for us as a community and for this tech movement. I think the virality of that particular thread wasn't so much a moment of genius as much as the right moment in time that captured where people's heads were collectively.
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Brian Armstrong6:58
Yeah, I agree. Looking back on this year, 2021, it did have this big moment where I think the whole crypto industry realized, 'Hey, we need to go engage more thoughtfully.' We were sort of used to being ignored, and people thought, 'Oh, it's a toy, let's ignore it,' and suddenly it was the biggest thing on everyone's radar in DC. So we all collectively realized it's now time to make an even bigger concerted effort to be an educational resource and close the gap on some of these massive misunderstandings, which are always shocking when you go over there. There are so many efforts going on in government relations now in the crypto space. Blockchain Association has been great, Coin Center has been great, Jerry Brito has been a secret weapon there for many years behind the scenes. The Crypto Council for Innovation is a new group that we're helping fund with a number of others. What would you say the crypto industry should be doing or needs to be doing in this regard to engage with the government even more? And we'll get to Web3 stuff, I just want to touch a little bit on the macro side.
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Ryan Selkis8:02
I think everyone's moving as fast as they possibly can in a lot of respects. It is important that there's follow-through and that these industry groups come together and people rally around them and we have a somewhat united message in some of these conversations. The reason I say that is it's an especially critical couple of quarters, and it's the reason I've been so outspoken on some of these issues, because I do think these next couple of quarters are critical in the sense that we have a bull market in our sales right now. We've got a lot of enthusiasm. First it was DeFi summer, then all the later ones rallied, then NFTs rallied. It's been the rotating 'hop all the money' trade where a lot of people have done very well, gotten excited, and there are a lot of applications that people are picking up on. We're getting close to, if not already crossing the chasm, especially with younger investors. If we can't capitalize on that now that we have regulator and policymaker attention, then when the market does turn the other direction, they're going to be able to use that against us. A lot of people got hurt, there weren't adequate disclosures and consumer protections. So the time to mobilize, get the funding, and get these policy teams in place both within companies and at these trade organizations and advocacy groups, I think it's now, and we have to capitalize on that. I think what Andreessen has done is amazing. If you want to go fast, go alone, and we need someone going fast right now while the rest of the industry tries to come together and have the broader alignment conversations between CCI, Blockchain Association, and Coin Center. I do think one of the things that is missing, and I've spoken about this more generally, is that we're going to need an individual member organization that is much more grassroots in its approach and isn't just an agent of the incumbent crypto institutions. I think that's very important, and that's probably where the rubber meets the road from regulation. But I think we want to make sure we continue to call out the individual self-sovereign element, and that's why I was so happy to see interoperability as a problem with a Coinbase proposal when it came out. I think that is going to go a long way towards giving people confidence that this is a good faith effort to engage with policymakers and not just an instance of the new gods replacing the old gods and having the set of regulatory capture that we're used to in every other emerging industry.
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Brian Armstrong10:53
Makes sense. Yeah, I think there's definitely a lot of different voices coming out. Coinbase came out with a proposal, FTX came out with one, and Andreessen has come out with some. I think there's a lot of voices, but they're all generally moving in the same direction. So I think the more efforts the better here. Hopefully, I agree with you about the grassroots movement too. I'd love to see an organization like CCI or any of these other ones help organize the crypto community, all the tens of millions of Americans and people outside of the US as well who have crypto, and they're voters, right? Because ultimately, the regulators are accountable to the elected politicians, and elected politicians are accountable to the people in a democracy. So the more product features that we can have, for instance, to help direct individual crypto holders in this district or in this zip code and say, 'Hey, go donate, here's an A or an F grade on local politicians,' and help them get movements going, that's been successful more so than a company going and lobbying. I think it's more powerful to have their constituents, their voters, going out. I also think we've taken sort of an apolitical stance at Coinbase except in regard to our mission, and our mission is advocating for crypto and economic freedom in the world. I've been happy to see that crypto is actually a pretty bipartisan issue in DC. There are people on the left and right who don't like it, and some people on the left and right who do like it, and there's a bunch in the middle who just don't know yet, they haven't made up their mind. So being that educational resource and having our constituents in all these districts who own crypto and are benefiting from it, I think that's ultimately how crypto wins: we just get more and more people using it and benefiting from it with all these new apps coming out, DeFi, NFTs, DAOs, and everything. So that's ultimately going to be the best defense I think we have for any incumbent or person who might want to harm crypto for their own purposes.
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Ryan Selkis12:44
I think that's 100% accurate. I actually think, given this administration's approval ratings and the straight shot down that it's been all year, there are whispers that one of the policies they're meeting with congressional leaders about and telling them to tone down and dial it back is around crypto. Why make any more enemies when right now things are shaping up to be pretty terrible for the Democrats as a party going into the midterms? Why would you turn off an entire base of young progressives that actually are passionate about this? That's been my biggest fear, that this gets politicized and becomes just another political football. But we're starting to see a slow sea change thanks to a couple of the Democratic senators and congressmen that stuck their neck out.
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Brian Armstrong13:41
Agreed. Yeah, I think it is going to be incredibly politically unpopular to attack crypto in some way. I mean, you're literally hurting people in their wallets who hold it if that's the case, but it's also just killing people's excitement about the future and all the cool things they can go build. There's kind of this 'we're all going to make it' vibe happening with NFTs right now. There's a sort of paternalistic vibe to what's happening too, which is saying, 'Hey, we're here to protect you,' but that means if you're not an accredited investor, you can't play in this space or something. I think some of those rules are actually kind of outdated. We need to rethink in America and probably in other countries what it means to be an accredited investor. The idea behind it is good: we're trying to protect people and have appropriate disclosures. I think everybody can get on the same page about that. Let's go get rid of the scams, go prosecute the frauds. But if you're actually just preventing people who aren't already wealthy from getting wealthy, it's paternalistic and it's actually harming equality. It's one of the most anti-equality things out there. So anyway, these are complex issues. I guess let's jump over to Web3. You write a lot in the report about some of your predictions for 2022. Do you want to give a high-level overview, or do you want to jump into the first area here that you mentioned around interoperability, because I think that's super interesting?
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Ryan Selkis15:00
Yeah, I mean, first I'll talk a little bit about the report itself. You kind of teased it in your intro. It's long, right? But for the fact that there's a lot going on in the industry, so there's a reason that this takes the amount of time that it does. We actually prioritize it, and I do say 'we' because it takes me so long that it distracts my focus from other parts of the business, and the team picks up the slack. But one of the reasons that we put this together is not only to have our own mental model for how the industry is evolving and what's coming around the corner, but to hopefully serve as a starting point for conversations across all of our customers, all the folks that we do business with, all of our investors. And no one else does it, right? So it's really trying to address what I think is a vacuum of information when it comes to having a Mary Meeker-style internet report. I'm not trying to say that I'm at the same level as Mary Meeker, but I do think that's important for an emerging industry that's moving as fast as crypto is. So that's kind of the starting point. The other thing is this is broken down into 120 sections, so you can literally go chapter by chapter, section by section, and digest it in bite-size increments depending on what you're diving deep on. I write it for myself to serve as an index, as I'm going back to a given topic: what can I cite, what do I know from memory, and how do I update my assumptions over the course of the year? My hope is that other people can use it in the same way. The first half of the report is basically narratives and key tailwinds, people to watch, which all have different themes associated with them, the regulatory update, Bitcoin and just Bitcoin, and then market infrastructure. That's the first half, section one, which can be very useful for institutions or basically any newcomer to the space. The second half is we're getting into Web3, and that's essentially four chapters: NFTs, which are obviously the theme of the year, the word of the year from Web3 or one of the dictionaries; DeFi and all the evolution that we've seen this year even though it's been in a secular bear market relative to the other assets; then the explosion of other layer ones and this multi-chain future that we're living in, how that infrastructure is ultimately going to be built and how these chains communicate with each other; and finally, how it's all governed, which really comes down to DAOs as an organizing primitive. So I think those four Web3 building blocks are each deserving of their own 20-page report, but that's more or less what we covered. I think you can't really have one without the other because that's going to be the foundation for many years to come, those four elements.
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Brian Armstrong17:50
That's great. Well, you cover a lot of ground in there. Do you want to start by talking a bit about the importance of interoperability between the layer ones and what you see emerging there? What do you think that will unlock?
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Ryan Selkis18:02
I think that was the biggest update to a lot of people's thesis this year: are we going to have one winner take all smart contract platform, and is ETH2 basically going to absorb the addressable universe of blockchain applications? I think the answer is no. We've kind of seen that now. Do we think there's going to be 30 different competing standards? Probably not, just because that would be a nightmare for developers and it would be difficult to replicate all the infrastructure that currently exists on Ethereum on five or six different stacks. So I think it really, to me right now, it's looking like anything that's EVM compatible, and then maybe anything that can plug into Polkadot, IBC, and Solana, are going to be the protocols and the sets of infrastructure that you need to pay attention to. I did not think that Ethereum was going to have a clear arrival at the beginning of the year. I'm still not really sure, but it's no longer 100% probability or close to it that Ethereum just runs away with it. They still have to deal with the merge, we've got to prove that there's good interoperability between layer one and layer two and between the different layer twos. There are a lot of up-and-coming ecosystems that are moving faster in different respects because they're making different security trade-offs.
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Brian Armstrong19:28
Agreed. I think it kind of all comes back to the power of scalability. The largest developer community is still around Ethereum, and we're seeing DeFi and NFTs, all these things that have gotten so much traction this year, are all really being built on Ethereum for the most part, not entirely. But the gas fees are just so high, it's punitive. It's like dial-up to broadband: people are going to go where they can get traction and scale. I think every time we bring the fees down by an order of magnitude, the number of applications goes up by an order of magnitude because they're sort of being prohibited today. In fact, you even saw with DeFi, someone like, how often do you do a loan or something like that? It's relatively few transactions that are needed, but the more you can develop these transactions where the average person is doing 100 transactions a day or maybe 100 transactions a minute, there are various applications that become possible in that world. So I guess, do you have a prediction on ETH2 and the layer twos versus say Solana or the other assets that you mentioned in terms of who's going to win developer mind share and get that new layer of scalability? It feels like there's a race that's on for who's going to be that dominant smart contract platform that's scaled and has the features people care about, like privacy or other things. Do you have a prediction how that's going to play out next year?
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Ryan Selkis21:03
I think the early returns on ZK rollups are very good. If early teams can prove that they're able to effectively develop using ZK tech on Ethereum layer 2, that to me is the foot race. Yes, there are other projects like Arbitrum and Optimism, but I think how quickly you can have layer one to ZK rollup seamless integrations and applications built on those chains, and then how well those different chains are able to communicate with each other, is going to dictate whether more mind share floods to IBC and the Cosmos ecosystem or whether something like Solana can really take off. Solana's interesting because they're making a fundamentally different set of trade-offs when it comes to security and decentralization. Ethereum obviously has the head start, and then you kind of have Polkadot and Cosmos lingering with their layer zero type approach, basically agreeing from day one that the most important thing is that different sovereign chains can talk to each other versus trying to create a master chain to rule them all. I would be surprised if Ethereum loses its head start just because of how much infrastructure has already been developed and because the scalability solutions are coming to market and they are moving quickly on them, and we know that they work at least for some applications like the IDEX and others that have already moved to L2. But I don't think it's a foregone conclusion like many people thought at the beginning, myself included. That's again been the biggest surprise for me.
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Brian Armstrong22:56
All right, I'll ask one other question and then we'll go to some questions from the audience. Let's talk a bit about DAO infrastructure. It feels, I don't know if you agree, I mean if NFTs were the word of 2021, I kind of feel like DAOs might be the word of 2022. I'm not sure. It feels like there needs to be a lot more infrastructure around DAOs. I think we're going to see more DAO M&A, I think we're going to see payroll needs to get done better. The Constitution DAO showed that some of the fundraising tools could probably be improved in certain ways. People weren't really sure what percentage of the total they were going to own because more and more money kept coming in. We're seeing really amazing stuff happening with City DAO, and there are just so many cool DAOs out there. What do you think the industry needs for DAO infrastructure, and is there an opportunity for Coinbase to help there and build something? What do you think the industry needs next?
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Ryan Selkis23:54
Well, first I'll start with the question for every new crypto-based product: do people want this, can it work, and then can it scale? Those are the three questions that you ask with everything. If you look historically, typically if you answer the first two questions in the affirmative—yes, people want this, and yes, it can work—then every time historically within crypto, that scalability challenge and the infrastructure challenge has been met, and you've seen a slate of very valuable company services and protocols that address that third bucket. This happened in NFTs, it's happened in DeFi, it's happening in transactions and stablecoins. I think the same is going to be true in governance. So what do you actually need to scale? You need a 100x improvement in information quality and throughput, and you ultimately need identity and reputation systems that allow you to delegate authority very quickly even through a decentralized organization. I think we've seen this with Friends With Benefits and some of the other DAOs that are starting to adopt this pod-like structure where you have different committees essentially that are delegated certain authority to work on either different components of the treasury spend or protocol developments. That is going to be standardized over a multi-year period, and there's going to be a slate of companies that deliver tools related to treasury management, workforce management, payroll, and everything that goes along with actually transforming companies into decentralized companies, which is no trivial task if you're trying to interface with the real world. That's where we're excited, that's where we've spent a lot of time. Going back to why we wrote this report, how DeFi is governed, how these layer 1 protocols get governed, is ultimately going to be dependent on DAO infrastructure, and a lot of DAO infrastructure is going to leverage non-fungible reputation tokens and other packets of information that are not fungible but rather earned and can be transferred from wallet to wallet if you're thinking about delegated authority within some of these organizations. So to me, I think you're right, I think 2022 is going to be the year of the DAO. With respect to Coinbase in particular, I don't know. I'm sure it's such a big theme that you and all the other major exchanges, wallets, custodians, and other infrastructure developers are going to be building tools around how these protocols are governed. The design space though is so incredibly massive that it's a good place to spend the next few years if you're a developer or a startup.
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Brian Armstrong26:46
Makes sense. I mean, I think Coinbase has 73 million verified users, but only a tiny fraction of those are probably even using DAOs or interfacing with them. Our whole thesis as a company really is how do we make all these new developments in crypto trusted and easy to use, and then hopefully we can help tens of millions more people come into it. I feel like we're behind; there's way more that we could be doing. I wish there were some simple tools already there today that allowed people to just see a list of DAOs and participate, and they could see proposals, they could have delegated voting like you said, and 'Hey, I trust this person, I'm going to delegate my votes to them' or whatever. That stuff could all be productized in the wallets in such a better way. So lots of work to do, no shortage of new opportunities sitting in front of us here. All right, you ready to do some questions from the audience?
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Ryan Selkis27:42
Yes, this is what I'm looking forward to.
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Brian Armstrong27:45
What do you think is the best way to mobilize crypto holders or HODLers to influence policy in the US and elsewhere? DAOs, PACs, coordinated voting efforts? How do we get that grassroots movement going?
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Ryan Selkis27:58
This one's a tough one because I think you do need a figurehead and a leader for this. It is one of those moments in time where everybody is struggling to keep their head above water and scale their own companies. The most likely candidates to lead something like this are probably among the group of folks that you already know, which would include me and probably include some other CEOs, and I just don't know how many of us are willing and able to step up and lead the charge on this as a dedicated effort. So having said all that, I am still kind of personally trying to find a small group or small organization that's going to take the mantle here, and then I'll personally throw my weight behind it and spend a good deal of time and effort and energy there because I think it's important. I do think you need someone that's going to be a catalyst and not a spokesman so much, but someone that we can hopefully capture that audience and get people to fund a winning organization so you can triage resources in the right direction. I think we probably need an advocacy group that has a political action committee and an education arm associated with it so you can play in both electoral politics and actively engage with some of these campaigns, but then also have a broader mandate to educate policymakers and create something like a congressional scorecard or other system to start triaging who are our friends, who are our enemies, and then holding them accountable when it comes time to vote every November.
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Brian Armstrong29:38
Agreed. Yeah, I've been excited to see more and more members of Congress now hosting and participating in fundraising dinners with the crypto community. That's been happening behind the scenes. There are enough people who have crypto now that really care about these issues, they're almost like single-issue voters. Someone made this comment to me: nobody in DC is really going to care until someone loses an election over it. I think that's probably true. We do need to turn out more and more voters and allocate these donations from the really large constituencies. We've got time for maybe just one more question here. So, 'Are Ethereum killer centralized chains a race to the bottom in terms of who can be fastest and cheapest?' I think the question is kind of asking: is it all about scalability and lowering fees, or are there ways that some of these other chains can differentiate?
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Ryan Selkis30:29
Honestly, I'm not sure. Right, it's all speed, scalability, security, and then censorship resistance, preventing de-platforming. So it is a combination, but I think the real pain point is around speed and costs, which is where a chain like Solana has been able to really come up the ranks and eat into Ethereum's dominance. The reason for that is relatively straightforward. We've been testing our governance products, and you have to rack up thousands of dollars just during the testing phase for not a lot of transactions. So you kind of extrapolate that to the startup in the garage or run out of a dorm room, and it's just not feasible. You have to find another stack to build on top of. I think that's okay as a temporary bottleneck, but the longer it persists, the more likely it is that we see developers and whole swaths of infrastructure make the trade-off and accept that, yes, this is a little bit more centralized, but the other chain is unusable or the other tech stack is unusable. This happened to a lesser extent with Bitcoin. Bitcoin was never as robust as Ethereum, was never designed to be a Turing complete computer. But I think we saw this play out in real time. I don't know about you, Brian, but for a long time I thought that Ethereum would be the smart contract programming language, but ultimately you'd be able to port Bitcoin to it and Bitcoin would still be the settlement currency and the reserve. That was disproven, and I think the same thing is happening now from layer one to layer one, and it will continue to happen over time for the medium term at least.
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Brian Armstrong32:26
Yep, well I think you're right. The race is on, and 2022 will be an interesting year to see who can achieve scalability and that developer mind share to build the next generation of apps, and that's going to bring in the next billion people into crypto. So it'll be very exciting to see. Well Ryan, we're out of time. I want to thank you very much for coming and spending the time with us. Thank you for being a champion for the industry and providing so much great research and insights into what people can see coming up in 2022 in crypto.