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Marianne De backer m.b.a., m.sc. on career history

From Vir Biotechnology: Marianne De Backer on Immuno-Oncology, Hepatitis Delta, and Biotech Turnarounds · · IDEA Pharma

“We are about one and a half billion dollar market cap public company here in San Francisco headquartered. I had a long career before becoming CEO of VI in the pharma industry. I started actually more than 30 years ago at Jansen. I knew Dr. Paul Jansen when he was still there and I started as a scientist, you know, local biologist. I worked about 10 years in drug discovery and then I did a rather drastic move into more, you know, corporate and business. So I did an MBA in finance and I went into you know licensing and business development and from there I actually went on to lead a commercial business. So I launched two products in Europe, one in iminology, one in neuroscience and then you know further evolved my career in corporate development. I did a lot of M&A and yeah I mean what has been driving me my entire career is bringing impact to patients. Uh, and I have been incredibly fortunate to do that in a lot of different ways.”

Marianne De backer m.b.a., m.sc.
Chief Executive Officer & Director, VIR BIOTECHNOLOGY INC
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On , Marianne De backer m.b.a., m.sc., Chief Executive Officer & Director at VIR BIOTECHNOLOGY INC, spoke about career history during Vir Biotechnology: Marianne De Backer on Immuno-Oncology, Hepatitis Delta, and Biotech Turnarounds on IDEA Pharma.

Vir Biotechnology: Marianne De Backer on Immuno-Oncology, Hepatitis Delta, and Biotech Turnarounds
Watch on YouTube at 0:42
Vir Biotechnology: Marianne De Backer on Immuno-Oncology, Hepatitis Delta, and Biotech Turnarounds
IDEA Pharma
Watch on YouTube at 0:42
In this episode of the IDEA Collider, host Mike Rea sits down with Marianne De Backer, CEO of Vir Biotechnology, to explore how she is leading one of biotech’s most complex transformations. After the rapid rise and decline of COVID-19 revenues tied to sotrovimab, Marianne stepped into Vir Bio in 2023 and led a bold strategic reset—refocusing the company on immuno-oncology, infectious disease, and platform-driven innovation. The conversation dives into Vir Bio’s next chapter, including its masked T-cell engager (TCE) pipeline and the PRO-XTEN® masking platform, which is designed to overcome the safety challenges of TCEs in the treatment of solid tumors by shielding therapies until they reach the tumor microenvironment. They also discuss Vir Bio’s advancing hepatitis delta program, currently in registrational Phase 3 trials, and the company’s growing pipeline leveraging the synergy of its AI-driven discovery, protein engineering capabilities, and universal PRO-XTEN® masking technology. Marianne shares what it takes to lead through a biotech downturn—from restructuring and capital discipline to rebuilding culture, integrating new teams, and positioning for long-term growth. This episode is a deep dive into biotech turnaround strategy, next-generation cancer therapies, and leadership in times of uncertainty. Episode Timestamps 00:00 – Introduction and Vir’s transformation story 00:40 – Marianne De Backer’s 30+ year pharma journey 02:42 – Vir’s origins and post-COVID strategic pivot 04:42 – Taking over as CEO during a crisis 06:33 – Lessons from the biotech downturn (“biotech winter”) 08:56 – Astellas partnership and T-cell engager strategy 09:52 – ProXtend platform: masked T-cell engagers explained 13:24 – Clinical data, safety, and tumor targeting 15:32 – Integrating new teams and scientific expertise 17:38 – Expanding the pipeline (HER2, EGFR, oncology) 19:50 – Hepatitis delta program and commercialization plans 22:11 – Funding strategy and biotech market outlook 25:37 – FDA interactions and regulatory perspective 28:13 – AI in drug discovery and clinical trials (Daisy platform) 31:34 – Culture: grit, ingenuity, collaboration, authenticity 34:21 – Personal reflections and leadership mindset 35:46 – Closing thoughts Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with Marianne De Backer; LinkedIn:   / marianne-d-de-backer-msc-phd-mba-73403411   Website: https://www.vir.bio/   Follow IDEA Pharma On; Website: https://www.ideapharma.com/ LinkedIn:   / idea-pharma     Listen to more fantastic podcast episodes: https://ideacollider.simplecast.com/
Marianne De backer m.b.a., m.sc.

About Marianne De backer m.b.a., m.sc.

Chief Executive Officer & Director · VIR BIOTECHNOLOGY INC

Marianne De Backer, CEO of Vir Biotechnology, discussed the company’s strategic turnaround in an April 2026 podcast interview. She noted that Vir Biotechnology was "incredibly successful during the COVID pandemic" with its drug sotrovimab, but after the virus evolved new variants, the company "went from a billion dollars in revenue one year to almost none the next." De Backer stated that she downsized the company by about one-third and closed some sites, adding that "cash is king" and that "you can have the best science and the best ideas in the world, but you need to fund your operations." De Backer described refocusing Vir Biotechnology on immuno-oncology and infectious disease, highlighting its masked T-cell engager pipeline and PRO-XTEN® masking platform. She said the company secured "more than a half billion in upfront income" through deals with Orion and Astellas, as well as a $173 million financing. De Backer also mentioned meeting with Dr. Mer Machi as part of a group of biotech CEOs, stating that "we are in a competitive global environment" and that she is "hopeful we will see changes to move faster across regulatory processes."

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