Jeff Hammerbacher: Extracting T cell function and differentiation characteristics
Many promising cancer immunotherapy treatment protocols rely on efficient and increasingly extensive methods for manipulating human immune cells. T cells are a frequent target of the laboratory and clinical research driving the development of such protocols as they are most often the effector of the cytotoxic activity that makes these treatments so potent. However, the cytokine signaling network that drives the differentiation and function of such cells is complex and difficult to replicate on a large scale in model biological systems. Abridged versions of these networks have been established…