Ep154: Robert Ang on CRISPR to Protect Bone Marrow & Attack Cancer
Robert Ang, CEO of Cambridge, Mass.-based Vor Bio, on using CRISPR gene editing to alter bone marrow transplants and improve treatment of acute myeloid leukemia.
Former President and CEO, Vor Bio
Search every verified Robert Ang interview, podcast appearance, and on-the-record quote — each transcript cross-checked by AI and human review to confirm speaker identity. Robert Ang, former president and CEO of Vor Bio, discussed the company's work using CRISPR gene editing to modify bone marrow transplants for treating acute myeloid leukemia (AML) in a February 2024 podcast appearance. He described the approach of deleting the CD33 antigen from blood-forming stem cells to shield them from a cancer drug targeting that marker, while leaving malignant cells vulnerable. Ang attributed the concept to scientific founder Sid Mukherjee, noting it originated from an idea about working on healthy cells rather than cancer cells directly. Ang also spoke about the company's next steps, emphasizing the transition from preclinical validation to demonstrating patient impact, with a focus on shifting disease trajectories for individual patients. He expressed personal fulfillment in his role, contrasting it with his earlier experience as a surgeon, and noted that the success of the approach would depend on the science.
Robert Ang, CEO of Cambridge, Mass.-based Vor Bio, on using CRISPR gene editing to alter bone marrow transplants and improve treatment of acute myeloid leukemia.
In 2021 on Episode 13, Vor Bio’s President and CEO, Dr. Robert Ang shared data about the company’s lead engineered hematopoietic cell (eHSC) product candidate. Dr. Ang is back to talk to Cell & Gene: The Podcast Host, Erin Harris, about how Vor has treated 8 patients demonstrating clinical proof of concept and is also in the clinic with a CAR-T that could be used in combination with shielded stem cell transplants. They also talk through Vor’s decision to build an internal cell therapy manufacturing facility co-located with their Cambridge, MA-based headquarters. -- #celltherapy #genetherapy…
There are exciting cell therapy developments that are poised to transform cancer treatment. Robert Ang, CEO at Vor Bio, shares the latest science the company is pursuing with ARM COO Rita Johnson-Greene. #cellandgenetherapy #CGMesa23
Dr. Robert Ang, President & CEO, Vor Biopharma Inc. Watch on TV! Click businessfirstam.com to find out where! Don't forget to Subscribe, Like and Share our channel - never miss an update!
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