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Aoife Brennan

President and Chief Executive Officer; formerly CEO, Synlogic, Climb Bio

Search every verified Aoife Brennan interview, podcast appearance, and on-the-record quote — each transcript cross-checked by AI and human review to confirm speaker identity. Aoife Brennan, President and Chief Executive Officer of Climb Bio and formerly CEO of Synlogic, discussed her work and leadership approach in an October 2019 podcast appearance. She described Synlogic’s focus on developing synthetic biology-based drugs, specifically engineering probiotic bacteria to perform targeted functions for treating diseases such as phenylketonuria (PKU), a genetic condition where the body cannot adequately clear phenylalanine from the blood. Brennan explained that the company aimed to give probiotics specific functionality to address damaged or missing biological processes in disease. In the same interview, Brennan reflected on her career path, including earlier roles in small companies and at Biogen, where she worked on multiple sclerosis programs despite not being a neurologist. She emphasized the importance of a science-driven culture and integrity in drug development, and described the CEO’s role as anticipating future organizational needs, such as structure and process, to support success over the next one to five years. She also noted the collaborative nature of the biotech community, where researchers and companies often support each other through challenges.

Recent appearances

  • Video Episode 67: Aoife Brennan, President and CEO of Climb Bio

    January 07, 2026 · 📺 Biorasi

    Let's kick off 2026 with the first ‪@BiorasiCRO‬ podcast episode of the year! How do you get "Biotech Vision" to see the complete picture of your place in the industry? Find out in the latest episode of the Few & Far Between podcast - How Biotech Gets Built. Host Chris O'Brien welcomes guest Aoife Brennan, President and CEO of #ClimbBio. We'll be discussing how to leverage science and strategy, the differences between CEOs and CMOs, and how hiring an "operational penknife" is critical to new organizations. Watch it today! #clinicaltrials #CROs #biotech

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  • Immune mediation, B-cell depletion, and female leadership – with Aoife Brennan

    July 17, 2025 · 📺 pharmaphorum media limited

    In a new pharmaphorum podcast, Aoife Brennan, CEO of Climb Bio, discusses the treatment of immune-mediated diseases. Climb Bio is a clinical-stage biotechnology company developing therapeutics for immune-mediated diseases, and Brennan talks about the potential of B-cell depletion therapies, as well as the challenges and opportunities in developing novel biotechnology. Brennan also speaks to being a female leader in this field. You can also listen to episode 191a of the pharmaphorum podcast (https://pharmaphorum.com/podcasts)  in the player below, download the episode to your computer,…

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  • Ep54: Aoife Brennan

    June 11, 2025 · 📺 The Long Run with Luke Timmerman

    CEO of Synlogic on developing synthetic biology-based drugs.

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  • The BioHub - The Avetix Podcast - S2 Ep40 - Aoife Brennan

    March 12, 2025 · 📺 The Biohub

    Welcome to the BioHub podcast where we interview the top minds from across the Biotech and Pharma industry. I’m joined by Aoife Brennan, CEO of Climb Bio—a company at the cutting edge of pioneering new approaches to cell and gene therapy. Aoife is a seasoned biotech leader with a track record of driving innovation. Before joining Climb Bio, she was the CEO of Synlogic, where she led the company through critical clinical advancements in engineered probiotic medicines. With a background in medicine and deep experience in biotech strategy, she has a unique perspective on bridging science a…

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  • Ep. 73 - Resilience and the CEO’s Paradox: Aoife Brennan on Leading in Biotech

    December 12, 2024 · 📺 BioCentury Video

    Leading biotech companies through the turbulence of the past few years and the uncertainty of the next ones takes not just resilience, but an ability to grapple with the CEO’s paradox, according to Climb Bio CEO Aoife Brennan. This paradox requires preparing for repeated setbacks while planning optimistically, a duality that has been the story of biotech since the outbreak of the pandemic, said Brennan. In conversation with Editor in Chief Simone Fishburn on The BioCentury Show, Brennan discusses how CEOs are managing through uncertainty, and why "boring" naked mAbs are the smart move in one f…

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  • Diversity in Biotech: Journey to Gender Equality with Dr. Aoife Brennan of Synlogic

    February 14, 2024 · 📺 Ellect

    In this episode of "From Bias to Equality Podcast", host Sandra D'Sousa sits down with Dr. Aoife Brennan, President, and CEO of Synlogic, a Nasdaq-listed biotech company. They delve into Dr. Brennan's inspiring career journey from med school to becoming a CEO of Symlogic, discussing challenges, family dynamics, and breaking gender barriers in the male-dominated biotech industry. Dr. Brennan shares insights on fostering diversity at the board and C-suite levels, the importance of thoughtful recruitment processes, and the impact of gender representation on company success. Tune in for an enligh…

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  • The Transatlantic Biotech Podcast Episode #1 w/ Aoife Brennan; CEO of Synlogic

    December 01, 2023 · 📺 Cranmore Executive Search

    Our guest, Dr. Aoife Brennan, CEO of Synlogic, shares insights on rare-disease therapeutics, US versus British/Irish biotech markets, fostering diversity, and advice for budding biotech professionals. Join us as we uncover the dynamic world of biotech entrepreneurship and leadership. 0:00 Introduction 1:44: The ups and downs of rare disease specialism 5:54: US v.s. Europe – How to secure investment as early-stage biotech 10:44: Is it worth it? 14:11: Achieving commercial success in biotech: the ‘who’ of fundraising 17:31: When the team dynamic isn’t clicking: Navigating difficult conversation…

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  • Phenomenal Women in biotech featuring Dr. Pardis Sabeti and Dr. Aoife Brennan

    June 03, 2022 · 📺 WBUR CitySpace, Boston

    Over the past decade a group of extraordinary women has changed the face of the biotech industry, becoming indispensable to the development of vaccines, genome sequencing, and cures to diseases. Join Radio Boston host Tiziana Dearing for a virtual conversation with two women who are paving the way: Dr. Aoife Brennan, President and CEO of Synlogic Inc., a clinical stage company creating transformative medicines, and Dr. Pardis Sabeti, who heads her own lab mapping the genome to discover new cures for diseases. Subscribe to WBUR CitySpace's YouTube channel here:    / @wburcityspace   Click o…

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  • Interview With Aoife Brennan, CEO, Synlogic Inc

    April 11, 2019 · 📺 Microbiome Times

    Kristina Campbell talks to Aoife Brennan to find out how Synlogic is pioneering the development of engineered probiotics to deliver specific functions in the human body to compliment for deficiencies brought about by disease.

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The summary and quote tags on this profile are produced with AI assistance from verified, first-person interview transcripts, then checked by our team to confirm the speaker's identity and the accuracy of every quote. See how we verify →