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Sean Saint

President and Chief Executive Officer, Beta Bionics, Inc.

Search every verified Sean Saint interview, podcast appearance, and on-the-record quote — each transcript cross-checked by AI and human review to confirm speaker identity. Sean Saint, President and CEO of Beta Bionics, has been active in 2024 and 2025 discussing the company's work on automated insulin delivery systems. In May 2024, he announced a formal partnership with Xeris Biopharma to develop a bi-hormonal insulin pump that would deliver both insulin and glucagon, describing the approach as mimicking the physiology of the human body by using glucagon to minimize hypoglycemia and potentially allow more aggressive management of high blood sugar. He noted that the primary challenge for such a product is achieving shelf-stable glucagon, which he said is necessary for a commercial product beyond the 24-hour stability of lyophilized versions. In earlier 2023 interviews following FDA clearance of the iLet Bionic Pancreas, Saint described the device as the first fully closed-loop insulin pump, requiring only the user's weight at setup and meal-size announcements without carb counting, and stated its goal is to bring users to an average A1C around 7.0 percent with less interaction, rather than targeting lower A1Cs. In a February 2025 podcast appearance, Saint reflected on his career path, including founding Companion Medical, which developed the first insulin smart pen, and his current role at Beta Bionics. He discussed lessons learned, such as valuing user experience, understanding metrics, and empathizing with customers, and emphasized that implementation constitutes the majority of value creation, saying "ideas are a dime a dozen." He also recounted that Companion Medical was initially managed with the goal of being acquired, but that the company ultimately pursued a standalone path, and he shared his view that failure only occurs when one quits, citing a phrase from his son: "You quit on a good day, not quit on a bad day."

Recent appearances

  • Sean Saint: Standalone Success

    February 15, 2025 · 📺 UCSF Rosenman Institute

    Getting startups off the ground is a challenging task. Founder of Companion Medical and CEO of Beta Bionics, Sean Saint (  / seansaint1  ) , tells us how he became a successful health tech founder in the diabetes care industry. From graduating with a mechanical engineering degree to founding companies with radical diabetes solutions, Sean made a lasting mark with the first insulin smart pen. Along the way, he’s learned three crucial steps: valuing user experience, understanding your metrics, and empathizing with the customer. In this episode, Sean will discuss his career path and lessons…

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  • #1209 Glucagon in an Insulin Pump

    May 26, 2024 · 📺 Juicebox Podcast

    Paul Edick and Sean Saint are CEOs of thier respective companies (Beta Bionics and Xeris). Today we talk about their new relationship and their desire to create a bi-hormonal insulin pump. Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED or call 888-721-1514 Learn about Touched By Type 1 Take the T1DExchange survey Free 14 Day Trial of Aura Eversense CGM Learn about the Medtronic Champions This BetterHelp link saves 10% on your first month of therapy Try delicious AG1 - Drink AG1.com/Juicebo…

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  • Episode 281 - The Future of Closed Loop Diabetes Therapy - Xeris Biopharma and Beta Bionics annou...

    May 21, 2024 · 📺 Rob Howe

    In this episode of Diabetics doing things, Rob interviews Paul Edick from Xeris Biopharma and Sean Saint from Beta Bionics. They discuss the formal partnership announcement between Xeris Biopharma and Beta Bionics, focusing on the development of a bi-hormonal insulin pump for diabetes management. The conversation touches on the challenges and benefits of the partnership, the development process, and the potential impact on diabetes care. Topics discussed: 1. Partnership between Xeris Biopharma and Beta Bionics 2. The unique challenges faced by a bihormonal pump compared to…

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  • What does it mean to "Go Bionic?" - A deep dive into the newly-approved iLet system

    June 06, 2023 · 📺 Diabetes Connections

    The newly FDA-approved iLet Bionic Pancreas is the most hands-off automated insulin delivery system to be commercially available. At set up, all you enter is your weight and the only interaction with the pump is to announce meal size, no carb counting. Stacey talks with Beta Bionics CEO Sean Saint. We go through this pump system in lots of detail, talk about future plans – yes we’ll talk dual chambered pump which is the original design here - and get a little philosophical about the idea behind a hands off system.. especially for those of us used to being much more in the driver’s seat.…

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  • Beta Bionics CEO Interview - iLet Bionic Pancreas

    June 05, 2023 · 📺 Diabetech

    🎧 Listen on Spotify, Apple Podcasts & more: https://www.diabetech.info The iLet Bionic Pancreas only requires one setting - your weight. I spoke with Beta Bionics CEO to ask about its newly FDA cleared insulin pump and what a future dual-hormone pump will look like. Gary’s practice: http://integrateddiabetes.com ▶️ Dexcom G7: One Month Review:    • Dexcom G7 Review: One Month Later   ▶️ Dexcom CEO Interview:    • Dexcom G7: CEO Interview - Your Questions ...   📱Follow me here: Instagram:   / diabe_tech   Tik Tok:   / diabe_tech   Facebook:   / diabetechjustin   Products I Recommend: Sug…

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The summary and quote tags on this profile are produced with AI assistance from verified, first-person interview transcripts, then checked by our team to confirm the speaker's identity and the accuracy of every quote. See how we verify →