We made it through the 4th of July. America is 250 years old. Welcome to the Sean Spicer Show. I hope you had a great 4th of July, saw fireworks, and spent time with family and friends. I love the 4th of July because it's a time to gather without the pressure of buying gifts. I spent time in New York at the International Labor Review and saw the fireworks display overseen by the president. It's unfortunate that this isn't a more unifying time, as polls show one party is not proud of America. CBS pollsters indicate the Democratic Party is not hopeful about the future. But I still believe this is the greatest country on Earth, and we should be proud of it. If you don't want to be here, I'd help you leave. But if you fight to come here, appreciate the splendor of this country. We need to do a better job of sharing that with the next generation. One of the things that concerns me is rising cancer rates in America. The government isn't doing enough to protect us from ultra-processed foods, dyes, and certain health recommendations. I'm excited to bring back Dr. Patrick Soon-Shiong, who is at the forefront of addressing this. He is using his wealth and intelligence to bring drugs to market, but the FDA has sent him a warning letter. I think it's a payoff to Big Pharma. Let me introduce the good doctor.
Seeing that people who'd been stable with cancer melanoma for years started relapsing at the beginning of 2022. I asked for any reason why and noticed they'd all been given boosters by their GPs. I wouldn't have done that. We found that boosters suppress the T-cell response. The first two increase it a bit, but a booster suppresses it. A group from Madrid published a paper showing T-cell exhaustion after third COVID vaccine in cancer patients. Any cancer suppressed by the immune system might pop up after the booster. Surgeons noted colorectal patients were presenting late and young, and all had the booster. I called a red flag that the vaccine might be involved in the cancer.
Are there any studies that have linked the mRNA to cancer? Is there any sort of medical process that you can allude to?
The strongest are the epidemiological studies, from Japan by Gibo and colleagues, which showed that the number of new cancer cases went up with each booster vaccine.
Okay, doctor, explain to me what we just heard. He said if you're getting the booster shot, you're suppressing the T-cell. Can you put in English what that means for the average person?
Okay, Krystal, let me unpack that. The evidence supports that the spike protein is involved. The COVID virus carries the spike protein on its surface, which enters cells through the ACE2 receptor. The spike protein, whether from booster, vaccine, or infection, causes inflammation and immunosuppression. There are many peer-reviewed papers showing increased incidence of cancer due to the spike protein. I can get into that.
The COVID virus carries on its surface a protein called spike, which enters the cells through the ACE2 receptor. The spike protein persists in the body and causes inflammation and immunosuppression. There's a paper from UC San Francisco showing the spike protein lasts up to 2 years in tissues. Another paper from the University of Virginia and Cedars-Sinai in Cell shows that the virus suppresses the immune system and increases lung cancer. A third paper from Spain shows spike protein in the cancer tissue itself. So three independent peer-reviewed articles show that if you have COVID infection, the risk of getting cancer is higher.
Okay. So, it seems to be saying millions of us have had COVID. Does that mean if you've had COVID, you're at higher risk of not being able to suppress a cancer cell?
Yes, it's not just if you had COVID, but the spike protein resides in your body. The vaccines are based on the spike protein. The most important question is the science around the spike protein. There's a paper by Tim Henrich at UC San Francisco showing persistence of the spike protein in colon, brain, and parotid tissues for up to 2 years. This is concerning because the hallmarks of a virus that increases cancer risk are persistence, inflammation, and immunosuppression. The spike protein appears to do all three. A paper in Cell from the University of Virginia and Cedars-Sinai shows that the virus stimulates a neutrophil that suppresses the immune system and increases lung cancer. Another paper from Spain shows spike protein in colorectal and anal cancer tissue. So we have three independent studies showing that viral infection like COVID increases the risk of cancer.
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That's the issue we'll face as scientists for the next decade. I was always fearful that if we didn't develop a treatment that clears the virus from your body, you'd end up in this state. The treatments are to clear the virus by activating macrophages, natural killer cells, and T cells. If you can activate those cells, you have a shot.
Is it correct that these tissue-based T cells remain in your body for up to 2 years? Does that mean after you've had COVID for 2 years, you're not at that same risk?
No, these aren't good T cells. They are sometimes exhausted T cells. A T cell can be good and kill, or suppress. When you have COVID and long COVID, you end up in an exhausted or suppressive phase, putting your body in a defenseless, pro-tumor position. This could explain the increased risk of cancer, especially in young people.
Okay. Considering how many people had COVID multiple times, do you believe we will see a major rise in cancer detection over the next couple decades?
I think we're already seeing that. Most oncologists are seeing it. Let me read from a paper published this month in Cell from the University of Pittsburgh, University of Virginia, Cedars-Sinai, and Mayo Clinic Jacksonville. It says patients previously hospitalized with severe COVID-19 have an increased risk of subsequent lung cancer. I don't want to sound the alarm for no reason, but clinicians are seeing higher instances of cancer and recurrences in patients who were in remission. Dr. Aditya Bhatia at UCLA presented at ASCO that breast cancer patients in complete remission got recurrences after COVID when their ALC was low. I've never seen metastatic pancreatic cancer in a 12-year-old boy before. I worry about this constantly. The world should come together to address this.
It says, and this is from the University of Pittsburgh School of Medicine, University of Virginia, Cedars-Sinai, Mayo Clinic Jacksonville, authors of this paper published this month in Cell, that patients previously hospitalized with severe COVID-19 have an increased risk of subsequent lung cancer. So clinicians are seeing higher instances of cancer and recurrences. I've never seen metastatic pancreatic cancer in a 12-year-old boy. I worry about this constantly.
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I can't answer that. It's very hard for me to answer why the government does what it does. But this is a real issue. The call to action is important. Maybe the United Nations or a larger body has to address this. In the private sector, we are trying. If we don't address this, it's a health crisis, a non-infectious pandemic. The World Health Organization has raised the alarm that the next wave in Africa is a non-infectious pandemic of cancer.
We talked about young people. From 1990 to 2019, the global incidence of early-onset cancer rose by 79%. What is driving this?
We've come full circle. It is not yet fully proven that COVID is oncogenic, but the evidence is growing. Viral infections like HPV and hepatitis cause cancer. If COVID is an oncogenic virus, we are in real trouble. We're seeing increased incidence of cancer, especially in young people, because the virus is immunosuppressing even a young body's immune system.
When you say 'if', is it a matter of time that we find this out, or do we need more data?
Evidence of oncogenic viruses takes time. We see double-stranded DNA persisting for 2 years at the site of infection. A patient from Spain had the COVID virus in the biopsy of the tumor cell. The question is whether it's an actor or a bystander. To be an actor, it must block p53 and other protective genes. That evidence is being developed. Until it's published and validated, I say 'if'. But I'm worried because the number of cancer patients, both young and relapsed, is increasing dramatically.
Beyond age, there is a gender issue. Women under 50 are 82% more likely to be diagnosed with cancer than their male counterparts. Breast and thyroid cancers make up nearly half. What is specific about the female anatomy causing this?
I'm not sure we fully understand, but you're right. I'm seeing high incidence of breast cancer in very young women and rapid recurrence in patients who were in remission. In prostate cancer, there's a gene that allows higher penetration of spike protein. Whether that exists in breast and thyroid remains to be explored. But it's part of the spike protein problem.
Specifically, colorectal cancer in young adults has skyrocketed and is now a leading cause of cancer-related deaths in young people. They recommend screening at 45. Is this another example of what's happening?
I've never seen metastatic pancreatic cancer in 11- or 12-year-olds. We now have reports of colorectal cancer in 10-year-olds. There has to be a relationship. Lynch syndrome affects about 2 million Americans and gives an 80% higher risk of colon cancer. If you combine that with an immunosuppressed environment from COVID, you get higher instance of cancer. The ACE2 receptor, which harbors the spike protein, has high levels in the colon and rectum. So circumstantial evidence points to the spike protein.
Is testing part of this? Is early detection key?
