Dominic D'Agostino

Associate Professor of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine

Ketone Metabolic Therapy – Applications, Methods, and Biomarker Monitoring - Dom D'Agostino - #CoSci

📅 Jan 09, 2025 Dave Feldman 33 MIN 10544 VIEWS 87 SEGMENTS · 2 SPEAKERS

[Heads up -- if you haven't already, consider coming to Las Vegas for our very next #CoSci conference this February 8th and 9th, 2025. For more details, visit CoSci.org] Dr. Dominic D’Agostino presents a compelling overview of his pioneering research in ketogenic metabolic therapy, focusing on its applications in health optimization, military resilience, and treating a broad range of conditions. He emphasizes the therapeutic potential of exogenous ketones and ketogenic diets in enhancing mitochondrial efficiency, managing neurological disorders, and exploring new biomarkers. Dr. D’Agostino in...

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Dr. Dominic D'Agostino is known for his research in nutritional strategies for health optimization and military resilience at the University of South Florida. Please welcome Dr. Dominic D'Agostino.

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APA, MLA, BibTeX

APA

D'Agostino, D. (2025, January 9). Ketone Metabolic Therapy – Applications, Methods, and Biomarker Monitoring - Dom D'Agostino - #CoSci [Interview transcript]. Dave Feldman. CEOInterviews.AI. https://ceointerviews.ai/interview/3128686/

MLA

Dominic D'Agostino. "Ketone Metabolic Therapy – Applications, Methods, and Biomarker Monitoring - Dom D'Agostino - #CoSci." Dave Feldman, 9 Jan. 2025. Transcript, CEOInterviews.AI, https://ceointerviews.ai/interview/3128686/.

BibTeX

@misc{dagostino2025_3128686,
  author       = {Dominic D'Agostino},
  title        = {Ketone Metabolic Therapy – Applications, Methods, and Biomarker Monitoring - Dom D'Agostino - #CoSci},
  howpublished = {Interview transcript, Dave Feldman. CEOInterviews.AI},
  year         = {2025},
  month        = {jan},
  url          = {https://ceointerviews.ai/interview/3128686/},
  note         = {Speaker-attributed transcript with timestamps}
}

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Key Quotes (2)

“So we simply know that elevating ketones within specific therapeutic ranges — and that can vary depending on the context — has therapeutic effects that includes anti-seizure effects, neuroprotective effects, it changes brain neuropharmacology, neurotransmitter systems, antioxidant mechanisms, inflammatory things. So we're just talking about ketones and not necessarily the ketogenic diet. We did a ”

▶ 4:36

“My LDL typically ranges from about 250 to upwards of 315 when I was on a 2:1 ketogenic diet, a clinical ketogenic diet. And to bring it down, not that I was super concerned about it, but I modified — I did a modified supplemented ketogenic diet with MCT and ketone supplementation and bumped up my protein; that decreased my LDL from 270 to about 190 to 200, which I kept for several years. And then ”

▶ 27:47 CONTROVERSIAL

More interviews with Dominic D'Agostino

Why The Ketogenic Diet Is So Important For Alzheimer's Prevention | Dr. Dominic D'AgostinoOct 23, 2026 · BrainHeal(th) · 60 min
New science of ketones for cancer, brain health, and insulin | Dr. Dominic D'AgostinoAug 26, 2026 · Inka Land, MSc · 81 min
The Ketogenic Diet with Dr. Dominic D'Agostino | Episode 34Aug 17, 2026 · Dr. Layne Norton Podcast · 141 min
Dr. Dominic D'Agostino Explains What Ketones Actually Do to Your Body | HOMe Podcast #021Aug 05, 2026 · Health Optimization Medicine Podcast · 52 min
Exogenous Ketones Explained - Dr. Dom D'AgostinoApr 27, 2026 · Metabolic Mind · 43 min
Dr. Dominic D'Agostino: Using metabolic Therapies to Prevent & Manage CANCERMar 17, 2026 · Dr. Thomas Seyfried (Charity Channel) · 122 min

All Dominic D'Agostino transcripts →

About Dominic D'Agostino

Dominic D'Agostino, an associate professor of molecular pharmacology and physiology at the University of South Florida Morsani College of Medicine and a research scientist at the Institute for Human and Machine Cognition, appeared in a 2016 interview discussing his research on metabolic-based therapies, including ketogenic diets, exogenous ketones, and metabolic drugs. His work has explored applications for seizure disorders, neurodegenerative diseases such as Alzheimer's, brain cancer, rare metabolic disorders, and oxygen toxicity, as well as human performance and extreme environments, including NASA's NEEMO missions. During the interview, he described his interest in ketogenic therapies as stemming from research on oxygen toxicity seizures and the challenges faced by Navy SEAL divers, and he stated that his laboratory continues to investigate mechanisms by which ketones may influence brain energy metabolism, neurotransmission, inflammation, and cellular signaling. In the same conversation, D'Agostino discussed practical approaches to exercise, suggesting that a structured progressive resistance program could involve incremental changes over time, potentially with bodyweight exercises or increasing weights, and noted that results might be achieved with two to three sessions per week. He also mentioned that he personally trains about one hour per week, with short, heavy sessions, and highlighted his involvement in the Metabolic Health Initiative, an accredited educational platform providing continuing medical education credits for doctors, as well as a public-service podcast called The Metabolic Link. A separate selected quote from the transcript sample, attributed to D'Agostino, discusses a "Vera" CPU opening a new market for NVIDIA, although this content appears unrelated to the interview's stated topic and is presented without additional context.

All Dominic D'Agostino appearances → Dave Feldman on YouTube →