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Dominic D'Agostino

Associate Professor of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine

Search every verified Dominic D'Agostino interview, podcast appearance, and on-the-record quote — each transcript cross-checked by AI and human review to confirm speaker identity. Dominic D'Agostino, an associate professor of molecular pharmacology and physiology at the University of South Florida Morsani College of Medicine and a research scientist at the Institute for Human and Machine Cognition, appeared in a 2016 interview discussing his research on metabolic-based therapies, including ketogenic diets, exogenous ketones, and metabolic drugs. His work has explored applications for seizure disorders, neurodegenerative diseases such as Alzheimer's, brain cancer, rare metabolic disorders, and oxygen toxicity, as well as human performance and extreme environments, including NASA's NEEMO missions. During the interview, he described his interest in ketogenic therapies as stemming from research on oxygen toxicity seizures and the challenges faced by Navy SEAL divers, and he stated that his laboratory continues to investigate mechanisms by which ketones may influence brain energy metabolism, neurotransmission, inflammation, and cellular signaling. In the same conversation, D'Agostino discussed practical approaches to exercise, suggesting that a structured progressive resistance program could involve incremental changes over time, potentially with bodyweight exercises or increasing weights, and noted that results might be achieved with two to three sessions per week. He also mentioned that he personally trains about one hour per week, with short, heavy sessions, and highlighted his involvement in the Metabolic Health Initiative, an accredited educational platform providing continuing medical education credits for doctors, as well as a public-service podcast called The Metabolic Link. A separate selected quote from the transcript sample, attributed to D'Agostino, discusses a "Vera" CPU opening a new market for NVIDIA, although this content appears unrelated to the interview's stated topic and is presented without additional context.

Recent appearances

  • Why The Ketogenic Diet Is So Important For Alzheimer's Prevention | Dr. Dominic D'Agostino

    October 23, 2026 · 📺 BrainHeal(th)

    Today, I am very honored to introduce Dr. Dominic D'Agostino. Dr. Dominic D’Agostino, PhD is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Research Scientist at the Institute for Human and Machine Cognition (IHMC). He earned his BS in Biological Sciences and Nutrition Science from Rutgers University and his PhD in Physiology and Neuroscience from the University of Medicine and Dentistry of New Jersey. His research focuses on metabolic-based therapies, including ketogenic diets, exogenous…

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  • New science of ketones for cancer, brain health, and insulin | Dr. Dominic D'Agostino

    August 26, 2026 · 📺 Inka Land, MSc

    Free 1:1 anti-aging and nervous system assessment call with me: https://calendly.com/inka-land/call Fix your sleep, focus, and energy (free assessment): https://www.skool.com/inkas-community... --- In this episode, I speak with Dr. Dominic D'Agostino, a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Research Scientist at the Institute for Human and Machine Cognition (IHMC). We discuss the biology of therapeutic ketosis, including the glucose-ketone index and its relevance to cancer a…

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  • The Ketogenic Diet with Dr. Dominic D'Agostino | Episode 34

    August 17, 2026 · 📺 Dr. Layne Norton Podcast

    In this episode of the Dr. Layne Norton Podcast, Layne sits down with renowned researcher and ketogenic diet expert Dr. Dominic D’Agostino to dive deep into the science of the ketogenic diet. Professor Dominic D’Agostino (University of South Florida Morsani College of Medicine / Institute for Human and Machine Cognition) is one of the leading voices on nutritional ketosis, exogenous ketones, and metabolic therapies. Together, they unpack what the research actually shows about keto – beyond the hype and social media claims. They cover the mechanisms of ketosis, potential therapeutic applicatio…

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  • Dr. Dominic D'Agostino Explains What Ketones Actually Do to Your Body | HOMe Podcast #021

    August 05, 2026 · 📺 Health Optimization Medicine Podcast

    In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Dominic D'Agostino, the premier researcher in ketogenic metabolic therapies. Moving past the mainstream fads of keto ice cream and internet trends, they break down how exogenous ketones actually impact cellular energy, cardiovascular health, and environmental stress. From the liver toxicity associated with certain high-dose ketone esters to the hidden vasodilatory superpowers of L-BHB, this discussion separates the biohacking hype from the physiological reality of ketone supplementation. Join us a…

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  • Exogenous Ketones Explained - Dr. Dom D'Agostino

    April 27, 2026 · 📺 Metabolic Mind

    Exogenous ketones have exploded in popularity, with claims ranging from better brain function to improved performance and weight loss. But what does the science actually say? In this in-depth conversation, Dr. Bret Scher sits down with leading ketone researcher Dr. Dominic D'Agostino (‪@ketonutrition-dom4845‬) to break down the reality behind exogenous ketones—what they are, how they work, and where they may (or may not) fit into your health strategy. They explore the key differences between: Endogenous ketones (produced by your body through diet or fasting) Exogenous ketones (supplements…

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  • Dr. Dominic D'Agostino: Using metabolic Therapies to Prevent & Manage CANCER

    March 17, 2026 · 📺 Dr. Thomas Seyfried (Charity Channel)

    Do you want to learn more? Visit our education community: https://skool.com/ketoforcancer Dr. Thomas Seyfried, discusses cancer as a metabolic disease. He holds a Ph.D. in Genetics and Biochemistry from the University of Illinois and has a background in neurology. Dr. Seyfried has received numerous awards and honors from various organizations, and he has over 150 peer-reviewed publications. He is also the author of the book "Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer," published in 2012. We are a group of enthusiastic fans, who want to support Prof. Se…

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  • How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — Dr. Dom D'Agostino

    January 06, 2026 · 📺 Tim Ferriss

    Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein…

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  • The Optimized Diet This Neuroscientist Feeds His Dogs — Dr. Dom D'Agostino

    September 12, 2025 · 📺 Tim Ferriss

    Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off) Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders) AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 t…

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  • Professor Dom D'Agostino: Finale

    September 08, 2025 · 📺 Dr. Casey Peavler - The Functional Medicine Doc

    🎁 Download the Free Metabolic Therapy Toolkit: https://caseypeavlersteamwo966b0.mycl... 🧭 Join the Press-Pulse Implementation Lab: https://www.skool.com/press-pulse-imp... 📅 Book a Consultation with Dr. Peavler: https://www.integrafunctionalmedicine... —————————————————————————— Welcome back fellow mitochondriacs! Today we drop part 2 of 2 from the sit down discussion I had with Professor Dom D'Agostino at USF in Tampa. We discuss multiple topics including ketones, oxidative therapies such as HBOT, and much more. The ONLY Red Light Therapy Device I use and recommend: Get 15% OFF EMR-Tek R…

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  • KETO = DEATH? The Science of Therapeutic Ketosis | Dom D'Agostino PhD

    September 05, 2025 · 📺 RobertLufkinMD

    Cardiologists say keto will kill you. The research says otherwise. Dr. Dom D'Agostino breaks down why ketones are a "magic shotgun" against obesity, heart disease, cancer, epilepsy, and aging itself. ⏱️ CHAPTERS: 0:00 - "This diet's going to kill you" 0:25 - Show intro 1:04 - Welcome Dom D'Agostino 1:26 - What is ketosis? BHB, AcAc, and measurement 2:07 - Most people never enter ketosis 3:42 - Keto origins: epilepsy and type 1 diabetes 5:34 - The magic shotgun: brain energy, GABA, epigenetics 6:00 - 72.7% of Americans are overweight 9:24 - Obesity, hypertension, heart disease, cancer, Alzheim…

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  • Professor Dom D'Agostino: Part 1

    September 01, 2025 · 📺 Dr. Casey Peavler - The Functional Medicine Doc

    🎁 Download the Free Metabolic Therapy Toolkit: https://caseypeavlersteamwo966b0.mycl... 🧭 Join the Press-Pulse Implementation Lab: https://www.skool.com/press-pulse-imp... 📅 Book a Consultation with Dr. Peavler: https://www.integrafunctionalmedicine... —————————————————————————— Welcome back fellow mitochondriacs! I had the honor of speaking with Dr. Dom D'Agostino who is a Professor at the University of South Florida in the Department of Molecular Pharmacology and Physiology. This will be part one of two of our conversation. The ONLY Red Light Therapy Device I use and recommend: Get 15…

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  • CLINICAL PEARLS - Dr. Dominic D'Agostino: Therapeutic Strategies with the Ketogenic Diet

    June 17, 2025 · 📺 The Clinician's Corner

    For this week’s episode of the Clinician’s Corner, we’re doing something differently. We have gone into the archives and pulled out clinical pearls from some of our favorite episodes, and we’re starting today with one of our most popular interviews with Dr. Dominic D’Agostino - where we unpack the ketogenic diet in all its nuances. This interview first aired back in 2023, and the full interview can be viewed here. Clinical pearls we extracted from the original interview: When the ketogenic diet is best used clinically; when it’s contraindicated; and how to structure it for best results What…

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Verified interview transcripts

Notable quotes

“The way to think about it is that up until now our data center business has been almost entirely GPUs. Vera is our CPU, and you know what's really exciting is that Vera opens a brand new 200 billion TAM for NVIDIA, a market we have never addressed before, and every major hyperscaler is partnering with us to get it deployed, and that's huge for the company because for the first time we have a second engine of that sca”

“I believe that context is super important and in the context of I guess you have the lean mass hyperresponder right you have other triglycerides are low HDL is high usually blood pressure is pretty low and everything in that context an elevated LDL probably has less cardiovascular risk over time because other things are in the optimal you know perceived optimal range. So you could make that argument but we don't have”

“The problem with a ketogenic diet will always be for many people the high fat. It is hard for especially for people who have a high metabolism to consume that amount of fat. And consuming that amount of fat every day, all day, every day, can produce some abnormalities in blood work that are maybe not perceived as like optimal. Although, my metabolism was pretty quick to shift over to fat and ketones. I did have a rem”

“I'm of the opinion that exogenous ketones as a monotherapy as an individual molecule as a monotherapy is not very good. It's much better when you combine different forms, like when you take if you can mix MCT with a DL beta-hydroxybutyrate salt, and then maybe titrate in a little bit of the acid. So, we're talking about formulation here, but you never see that in the peer-reviewed journals because everybody has a com”

“I think for people who have food allergies and for people who are willing to adhere to it, simply eating meat, liver, fish, beef, things like that can be therapeutic. And I think a lot of the positive results happen because the carnivore diet's preserving muscle mass. It's also controlling appetite in a way that creates a caloric deficit. And by virtue of creating a caloric deficit, you are suppressing the hormone in”

“The things to consider would be when you're thinking about a ketone supplement to think about palatability. If it doesn't taste okay, you're not going to consume it. I would, but most people won't. Palatability, tolerability, if it gives you disaster pants or it makes you nauseous or something. So, palatability, tolerability, and then the next one, the third one would be the pharmacokinetics. So, you want something t”

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