Host6:01
Yeah. Is it, yeah. It was like is it over? You start thinking about the consequence of this and you don't need to get to AGI super intelligence god. You can just have a really powerful tool that creates a new problem and that creates full employment for Nikesh Arora over at Palo Alto Networks who we had a chance to talk to yesterday and he's been very fortunate in implementing the solutions to the cyber security threats posed by new AI systems some of the new AI capabilities they're rolling out. But bio might be next. And so it's exciting to see that the great houses of AI are uniting behind the bio threats. So let's take you through this. First I'm going to tell you about console.com. Console builds AI agents that automate 70% of IT HR and finance support giving employees instant resolution for access requests and password resets. So in 1981 a group of researchers published the primary structure of the polio virus genome in the journal Nature. So they're basically open sourcing the sequence for making polio which just a few years earlier polio I think was on the decline by 1981 but a very very problematic virus. It's an RNA virus meaning that its nucleobases or building blocks are ACGU if you're familiar with RNA adenine, cytosine, guanine, and uracil. Put more plainly, thanks Brandon Guerell, he says when the researchers published the primary structure of the polio virus, they gave the world the literal sequence of polio virus building blocks in order from start to finish. By the mid-20th century, before mass vaccination, polio was paralyzing and killing more than half a million people per year worldwide. So you have this pretty deadly virus killing more than half a million people per year worldwide. And you have just open sourced it. What happens? So in 2002, researchers synthesized infectious polio virus from its publicly available sequence data. So they didn't actually need any of the polio virus RNA to start. They didn't need it on hand. They didn't need to. It's not like they took a little sample and they just cloned it up and made it bigger. They just took the data and they made the actual virus. So this is the shape of the threat. If there's a new virus or an existing virus or a forgotten about virus and you have the code to it, you can potentially print that RNA and then have the virus in your hands. Even if you don't have a sample, you weren't able to kill a sample. So instead, these researchers in 2002, they were able to take the published sequence, chemically synthesize short DNA fragments, assemble them into a full length DNA copy of the polio virus genome, and then use the DNA to make the viral RNA to fully recover the infectious virus. So in 2005, researchers used these same technologies to reconstruct the Spanish flu, a virus in 1918 that killed 675,000 Americans and had a 2 to 3% mortality rate among those infected. Very, very dangerous stuff. So basically, these two reconstructed viruses showed that having a physical virus on hand was no longer necessary as source material to create viruses. All you needed was the blueprints. As long as you have the code literally just like texted in a text file a bunch of ACGU, you can go and make this as long as you have the equipment on hand but that is getting democratized as well and that's what this AI letter is all about. So that's a situation that we're still in today except now that we have AI there are easier ways to potentially reconstruct DNA sequences that could create new viruses. So yesterday, Demis Hassabis, Sam Altman, Dario Amodei, Alex Wang, and dozens of other high-profile leaders across AI, tech policy, nucleic acid synthesis, and biotech signed an open letter called in support of mandatory nucleic acid synthesis screening, and recordkeeping. You might have seen it on the timeline. And at first glance, Brandon here assumed, and I assumed the same thing, assumed it was another press release from a Frontier Lab claiming it had just discovered new capabilities in one of its internal models that would ultimately lead to catastrophe. A lot of this doom fear-based marketing has been happening. So, that was sort of the natural reaction. And that's what Brandon...