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Seema Amble

Partner, Andreessen Horowitz

Verified interview transcripts, podcast appearances, and direct quotes from Seema Amble, Partner at Andreessen Horowitz. AI-verified speaker identity with full-text searchable transcripts.

Recent appearances

  • Why Enterprise Software Is Being Rebuilt Around AI Agents

    October 02, 2026 · 📺 a16z

    a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record. Their answer comes down to the work that happens outside those systems. In procurement, a final price in an ERP can hide hundreds of emails, spreadsheets, supplier conversations, engineering analyses, and decisions across legal, finance, and operations. Vlad explains how Lio uses multi-agent systems to take on more of that end-to-end work, from sourcing and RFQs t…

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  • The New Rules of Enterprise Software with Steven Sinofsky

    July 07, 2026 · 📺 a16z

    Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the primary users of software instead of humans? The conversation explores the rise of "headless" software, why APIs and agentic workflows are reshaping enterprise applications, and whether traditional SaaS products are becoming systems of record rather than systems of engagement. They discuss Salesforce's Headless 360 announcement, MCP, enterprise software architecture, and why AI may fundamentally change how businesses interact with their data. A…

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  • Sequence Collect | What's next in the CFO stack with a16z

    November 05, 2025 · 📺 SequenceHQ

    Jump inside A16z. Partners Seema Amble and Ivan Makarov share their insights on what's next for the CFO suite as part of our annual Collect conference

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  • Building a $20B+ Open Source Business with MongoDB and Viam's Eliot Horowitz

    December 13, 2024 · 📺 a16z

    a16z Partner Seema Amble talks with MongoDB and Viam co-founder Eliot Horowitz about building sustainable open source software tools. From challenging Oracle to building the de facto cloud-based database management tool, Horowitz outlines MongoDB’s early go-to-market strategies, approach to community building, and enterprise sales motion. This episode provides detailed tips on creating solutions for the developer community, building trust amongst enterprises, and successfully scaling a business supported by the open source community.

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  • How GenAI-Based Software Is Advancing Marketing and Sales

    November 21, 2024 · 📺 a16z

    In this conversation, a16z Partner Seema Amble and a16z Podcast Host Steph Smith discuss the changing role of marketing in a $500 billion industry. In particular, they highlight how generative AI tools are reshaping everything from content creation to data-driven insights. 💡 Key Takeaways Shifting Roles: Marketers are moving from hands-on creators to strategic reviewers, empowered by AI-driven automation. Game-Changing Tools: AI enables hyper-personalization, real-time research, and the seamless integration of sales and marketing. Challenges Ahead: Trust, content quality, and brand co…

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  • [ENG] #127 - Seema Amble (a16z) - Inspiration from within an incredible VC

    October 01, 2024 · 📺 Finscale

    In this episode, we look at the US and Europe through the lens of the fintech medium-term landscape, and deep dive into what the European start-up scene means to a giant US VC firm and what they look for when investing.  Seema Amble is a partner at Andreessen Horowitz (A16Z), the venture capital firm specialising in early-stage start-ups and established growth companies. Prior to this, Seema had been investing in fintechs for over a decade, primarily covering financial services with a focus on payments and insurance.It’s very insightful to get Seema’s fintech’s medium-term outlook and learn…

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  • Why a16z is All-In on AI for Finance Teams with Partner Seema Amble

    August 01, 2024 · 📺 Tech Finance with Sasha Orloff

    In this episode, Sasha sits down with Seema Amble, Partner at Andreessen Horowitz. Seema shares her research on the transformation of the CFO’s office, and how generative AI is powering financial teams. She discusses how AI can empower CFOs and finance teams to focus on strategic rather manual tasks, increasing client communication through automation, the impact of AI on valuations in service businesses such as law and accounting, and the progression from “service as a software” vs “software as a service”. Seema also discusses investing cycles, and how AI adoption in enterprise might follow th…

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  • Launching a New Category with Modern Treasury's Dimitri Dadiomov

    December 12, 2023 · 📺 a16z

    In a new episode of My First 16, a16z partner Seema Amble talks with Dimitri Dadimov, the co-founder and CEO of payment operations platform Modern Treasury, about the challenges of creating a new category, hiring for marketing before you hire for sales, and why developing new features is similar to birding. My First 16, a new video podcast from a16z, features interviews with founders and CEOs of fintech companies about how they acquired their initial customers and the hard lessons they learned along the way. Stay tuned to a16z’s YouTube channel (and this dedicated playlist, My First 16) for…

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  • Welding Yourself to Early Customers with Marqeta's Jason Gardner

    November 28, 2023 · 📺 a16z

    In a new episode of My First 16, a16z partner Seema Amble talks with the founder and current executive chairman of Marqeta Jason Gardner about what it means to be welded to your customer and how to expand in multiple verticals. My First 16, a new video podcast from a16z, features interviews with founders and CEOs of fintech companies about how they acquired their initial customers and the hard lessons they learned along the way. Stay tuned to a16z’s YouTube channel (and this dedicated playlist, My First 16) for more episodes, coming soon! Stay connected with a16z for more updates from the F…

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  • Doubling Down on Founder-Led Sales with Pilot's Waseem Daher

    November 21, 2023 · 📺 a16z

    In a new episode of My First 16, a16z partner Seema Amble talks with co-founder and CEO of Pilot Waseem Daher on how he thought about the importance of charging, how secondary signals often matter in an area like accounting, and never stepping away from doing founder-led sales. My First 16, a new video podcast from a16z, features interviews with founders and CEOs of fintech companies about how they acquired their initial customers and the hard lessons they learned along the way. Stay tuned to a16z’s YouTube channel (and this dedicated playlist, My First 16) for more episodes, coming soon! S…

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  • Competing in a Crowd of Incumbents with Mercury's Immad Akhund

    November 14, 2023 · 📺 a16z

    In a new episode of My First 16, a16z partner Seema Amble talks with co-founder and CEO of Mercury Immad Akhund about the idea of a “minimum delightful product” in fintech, doing the spreadsheet math on unit economics early on, and how to compete in a category already filled with incumbents. My First 16, a new video podcast from a16z, features interviews with founders and CEOs of fintech companies about how they acquired their initial customers and the hard lessons they learned along the way. Stay tuned to a16z’s YouTube channel (and this dedicated playlist, My First 16 on the a16z website:…

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