Reid Hoffman, co-founder of LinkedIn and a partner at Greylock, has been active in discussions about artificial intelligence, entrepreneurship, and politics. He stated that he believes there is a greater than 50% chance of repercussions from the Trump administration for his efforts to help elect Kamala Harris. Hoffman has argued that AI has a negative perception in the US and Europe compared to a positive one in Asia, and he expressed concern that the US and Europe risk falling behind if they slow AI development. He predicted that the workforce will shift to a model where people manage groups of AI agents rather than working as individual contributors. Hoffman has also been promoting his AI-driven drug discovery company, Manifold AI, and asserted that AI offers the best chance in history of curing all cancer. He said that patients and doctors who do not use frontier AI models as a second opinion for serious conditions are "bordering on committing malpractice." In the crypto space, Hoffman stated he has held Bitcoin since 2014 and has not sold any, and he argued that crypto is the only viable solution for identity and trust as AI agents proliferate online. He also criticized what he called the "greatest kleptocracy" of his lifetime, referencing corruption in government and business.